Gabanyi Margaret J, Adams Paul D, Arnold Konstantin, Bordoli Lorenza, Carter Lester G, Flippen-Andersen Judith, Gifford Lida, Haas Juergen, Kouranov Andrei, McLaughlin William A, Micallef David I, Minor Wladek, Shah Raship, Schwede Torsten, Tao Yi-Ping, Westbrook John D, Zimmerman Matthew, Berman Helen M
Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
J Struct Funct Genomics. 2011 Jul;12(2):45-54. doi: 10.1007/s10969-011-9106-2. Epub 2011 Apr 7.
The Protein Structure Initiative's Structural Biology Knowledgebase (SBKB, URL: http://sbkb.org ) is an open web resource designed to turn the products of the structural genomics and structural biology efforts into knowledge that can be used by the biological community to understand living systems and disease. Here we will present examples on how to use the SBKB to enable biological research. For example, a protein sequence or Protein Data Bank (PDB) structure ID search will provide a list of related protein structures in the PDB, associated biological descriptions (annotations), homology models, structural genomics protein target status, experimental protocols, and the ability to order available DNA clones from the PSI:Biology-Materials Repository. A text search will find publication and technology reports resulting from the PSI's high-throughput research efforts. Web tools that aid in research, including a system that accepts protein structure requests from the community, will also be described. Created in collaboration with the Nature Publishing Group, the Structural Biology Knowledgebase monthly update also provides a research library, editorials about new research advances, news, and an events calendar to present a broader view of structural genomics and structural biology.
蛋白质结构计划的结构生物学知识库（SBKB，网址：http://sbkb.org ）是一个开放的网络资源库，旨在将结构基因组学和结构生物学研究成果转化为可供生物学界用于理解生命系统和疾病的知识。在此，我们将展示如何利用SBKB推动生物学研究的实例。例如，通过蛋白质序列或蛋白质数据库（PDB）结构ID搜索，可获取PDB中相关蛋白质结构的列表、相关生物学描述（注释）、同源模型、结构基因组学蛋白质靶点状态、实验方案，以及从PSI：生物学材料库订购可用DNA克隆的能力。文本搜索可找到PSI高通量研究工作产生的出版物和技术报告。还将介绍有助于研究的网络工具，包括一个接受来自科学界蛋白质结构请求的系统。与自然出版集团合作创建的结构生物学知识库月度更新内容还提供一个研究文库、关于新研究进展的社论、新闻以及一个活动日历，以更全面地展示结构基因组学和结构生物学。
