Faculty of Medicine, Department of Urology, University of Inonu, 44280 Malatya, Turkey.
Cancer Chemother Pharmacol. 2012 Jan;69(1):207-13. doi: 10.1007/s00280-011-1692-y. Epub 2011 Jun 17.
In the current study, the protective effect of montelukast (ML) on cisplatin induced reproductive toxicity in rats was investigated. Twenty-eight rats were equally divided into four groups; first group was kept as control. In the second group, ML was orally administered at the dose of 10 mg/kg/day for 10 days. In the third group, CP was intraperitoneally administered at the dose of 7 mg/kg a single injection, and in fourth group, CP and ML were given together at the same doses. Although CP induced oxidative stress via significant increase in the formation of TBARS, it caused a significant decline in the levels of GSH, CAT, GPx, and SOD in rats. In contrast, ML prevents these effects of CP through cause an increase in GSH, CAT, GPx, and SOD levels and a decrease in formation of TBARS. In addition, sperm motility and serum testosterone levels significantly decrease and histopathological damage increases with CP treatment. However, the effects of CP on sperm motility, serum testosterone level, oxidative and histopathological changes are eliminated by ML treatment. In conclusion, the current study demonstrated that the reproductive toxicity caused by CP may be prevented by ML treatment. Thus, it was judged that co-administration of ML with CP may be useful to attenuate the negative effects of CP on male reproductive system.
在本研究中，研究了孟鲁司特（ML）对顺铂诱导的大鼠生殖毒性的保护作用。将 28 只大鼠等分为四组；第一组作为对照组。第二组大鼠连续 10 天每天口服 ML 10mg/kg。第三组大鼠腹腔内注射 CP 一次，剂量为 7mg/kg。第四组大鼠同时给予 CP 和 ML，剂量与前两组相同。虽然 CP 通过显著增加 TBARS 的形成诱导氧化应激，但它导致大鼠体内 GSH、CAT、GPx 和 SOD 水平显著下降。相反，ML 通过增加 GSH、CAT、GPx 和 SOD 水平并减少 TBARS 的形成来预防 CP 的这些作用。此外，CP 处理会导致精子活力和血清睾酮水平显著下降，组织病理学损伤增加。然而，CP 对精子活力、血清睾酮水平、氧化和组织病理学变化的影响被 ML 治疗消除。总之，本研究表明，CP 引起的生殖毒性可通过 ML 治疗预防。因此，判断 CP 与 ML 联合使用可能有助于减轻 CP 对男性生殖系统的负面影响。
