Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York City, New York 10032, USA.
Depress Anxiety. 2011 Aug;28(8):686-95. doi: 10.1002/da.20842. Epub 2011 Jun 16.
Although many patients with posttraumatic stress disorder (PTSD) experience a reduction in posttraumatic symptoms over time, little is currently known about the extent of their residual functional impairment. This study examines functional impairment in primary care patients with a history of PTSD as compared to patients with current PTSD, and those who never developed PTSD following exposure to trauma.
The sample consisted of 321 trauma-exposed low-income, predominantly Hispanic adults attending a large urban primary care practice. PTSD was assessed with the Lifetime Composite International Diagnostic Interview and other psychiatric disorders with the SCID-I. Physical and mental health-related quality of life was assessed with the Medical Outcome Health Survey (SF-12), and functional impairment with items from the Sheehan Disability Scale and Social Adjustment Scale Self-Report.
Logistic regression analyses controlling for gender, psychiatric comorbidity, and interpersonal traumas showed that although patients with past PTSD function significantly better than patients with current PTSD, they experience persisting deficits in mental health-related quality of life compared to trauma-exposed patients who never developed PTSD. Overall, results revealed a continuum of severity in psychiatric comorbidity, functioning, and quality of life, with current PTSD associated with the most impairment, never having met criteria for PTSD with the least impairment, and history of PTSD falling in between.
In this primary care sample, adults with a history of past PTSD but no current PTSD continued to report enduring functional deficits, suggesting a need for ongoing clinical attention.
尽管许多创伤后应激障碍(PTSD)患者随着时间的推移会减少创伤后症状,但目前对于他们残留的功能障碍程度知之甚少。本研究比较了有 PTSD 病史的患者、目前患有 PTSD 的患者以及创伤后从未发展为 PTSD 的患者的功能障碍程度。
该样本由 321 名在大型城市初级保健机构就诊的创伤后低收入、以西班牙裔为主的成年人组成。创伤后应激障碍采用终身综合国际诊断访谈进行评估,其他精神障碍采用 SCID-I 进行评估。身体和心理健康相关生活质量采用医疗结果健康调查(SF-12)进行评估,功能障碍采用 Sheehan 残疾量表和社会适应量表自我报告的项目进行评估。
在控制性别、精神共病和人际创伤的情况下进行逻辑回归分析显示,尽管过去患有 PTSD 的患者功能明显优于目前患有 PTSD 的患者,但与从未发展为 PTSD 的创伤暴露患者相比,他们在心理健康相关生活质量方面仍存在持续的缺陷。总体而言,结果显示出精神共病、功能和生活质量严重程度的连续体,目前患有 PTSD 与最严重的损伤相关,从未符合 PTSD 标准的损伤最小,而过去患有 PTSD 的损伤介于两者之间。
在这个初级保健样本中,过去患有 PTSD 但目前没有 PTSD 的成年人继续报告持久的功能缺陷,这表明需要持续的临床关注。