Sakai Takehiro, Tsushima Takao, Kimura Daisuke, Hatanaka Ryo, Yamada Yoshitsugu, Fukuda Ikuo, Tachibana Masato
Department of Thoracic and Cardiovascular Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Kyobu Geka. 2011 Jun;64(6):483-6.
A 76-year-old man, who had underwent radiation for laryngeal cancer 5 years before, was pointed out abnormal pulmonary lesion on computed tomography. The 4.6 cm-sized lesion was seen in the upper lobe of the left lung. Endoscopic brushing cytology revealed adenocarcinoma. The patient was diagnosed as primary lung cancer of T2N0M0, clinical stage IB. Preoperative serum CA19-9 was elevated to 250 U/ml, although other tumor markers were within normal limits. The patient underwent left upper lobectomy with mediastinal lymph node dissection. Histologically, the lesion was diagnosed as well differentiated adenocarcinoma, mucinous subtype of bronchioloalveolar carcinoma (BAC) in World Health Organization (WHO) classification. Immunohistochemistry shows positive for CA19-9 and thyroid transcription factor-1 (TTF-1).
一名76岁男性，5年前曾因喉癌接受放疗，此次计算机断层扫描显示肺部有异常病变。在左肺上叶发现一个4.6厘米大小的病灶。内镜刷检细胞学检查显示为腺癌。该患者被诊断为T2N0M0期原发性肺癌，临床分期为IB期。术前血清CA19-9升高至250 U/ml，而其他肿瘤标志物均在正常范围内。患者接受了左上叶切除及纵隔淋巴结清扫术。组织学检查显示，该病灶被诊断为世界卫生组织（WHO）分类中的高分化腺癌，黏液型细支气管肺泡癌（BAC）。免疫组化显示CA19-9和甲状腺转录因子-1（TTF-1）呈阳性。
