Department of Medical Oncology, University Military Hospital, Rabat, Morocco.
World J Surg Oncol. 2011 Jun 17;9:65. doi: 10.1186/1477-7819-9-65.
In the ovary, metastatic malignant melanoma may be confused with primary malignant melanoma and presents a diagnosis challenge. Most cases are associated with disseminated diseases and poor prognosis. We present this case report of a metastatic ovarian malignant melanoma simulating primary ovarian cancer.
A 45-year-old premenopausal woman was incidentally found to have an abdominal mass, 3 years after removal of a cutaneous melanoma lesion. Ultrasound and CT scan revealed left two solid masses, which were found to be an ovarian tumor at laparotomy. Left oophorectomy was performed. Histopathology and immunohistochemistry showed melanoma metastasis to the ovary. Nine months later, the patient developed epilepsy and confusion. Magnetic Resonance Imaging showed unique Wright frontal lobe lesion. She underwent stereotactic radio surgery and dacarbazine monotherapy. For months later, the patient is died from disseminate disease progression.
Ovarian metastasis is an unusual presentation of cutaneous melanoma and the prognosis was dismal. As illustrated by this case report, a differential diagnosis of a metastatic malignant melanoma must be considered.
在卵巢中，转移性恶性黑色素瘤可能与原发性恶性黑色素瘤混淆，诊断具有挑战性。大多数病例与播散性疾病和预后不良相关。我们报告了一例转移性卵巢恶性黑色素瘤模拟原发性卵巢癌的病例。
一名 45 岁的绝经前妇女在切除皮肤黑色素瘤病变 3 年后偶然发现腹部肿块。超声和 CT 扫描显示左侧有两个实性肿块，剖腹探查发现为卵巢肿瘤。行左侧卵巢切除术。组织病理学和免疫组织化学显示黑色素瘤转移至卵巢。9 个月后，患者出现癫痫和意识模糊。磁共振成像显示独特的 Wright 额叶病变。她接受了立体定向放射手术和达卡巴嗪单药治疗。数月后，患者死于疾病广泛进展。
卵巢转移是皮肤黑色素瘤的一种罕见表现，预后不良。正如本病例报告所示，必须考虑转移性恶性黑色素瘤的鉴别诊断。
