Bourou Maria Zoi, Panoskaltsis Theodoros, Myoteri Despoina, Korompelis Porfyrios, Vakas Panagiotis
Second Department of Obstetrics and Gynecology, National and Kapodistrian University of Athens Medical School, Aretaieio University Hospital, Athens, GRC.
Department of Pathology, National and Kapodistrian University of Athens Medical School, Aretaieio University Hospital, Athens, GRC.
Cureus. 2025 May 16;17(5):e84249. doi: 10.7759/cureus.84249. eCollection 2025 May.
Primary ovarian melanoma (POM) is an exceedingly rare and aggressive form of melanoma that arises in the ovaries, distinct from metastatic ovarian melanoma, which is far more common. The rarity of this condition, coupled with its clinical similarities to other types of ovarian malignancies, makes it a challenging entity to diagnose and manage. We present the case of a 56-year-old woman who underwent a laparoscopically assisted vaginal hysterectomy and bilateral salpingo-oophorectomy due to pelvic organ prolapse and a left adnexal mass. The final histology showed a POM. She received adjuvant immunotherapy, and a year after the initial diagnosis, the patient remains alive and well, without any signs of recurrence or distant disease.
原发性卵巢黑色素瘤（POM）是一种极为罕见且侵袭性强的黑色素瘤，起源于卵巢，与更为常见的转移性卵巢黑色素瘤不同。这种疾病的罕见性，再加上其与其他类型卵巢恶性肿瘤在临床上的相似性，使得它成为一种难以诊断和处理的病症。我们报告一例56岁女性病例，该患者因盆腔器官脱垂和左侧附件包块接受了腹腔镜辅助阴道子宫切除术及双侧输卵管卵巢切除术。最终组织学检查显示为原发性卵巢黑色素瘤。她接受了辅助免疫治疗，在初次诊断一年后，患者仍然健在，没有任何复发或远处疾病的迹象。
