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先兆子痫中环鸟苷酸水平的改变可能反映了 B 型利钠肽水平的增加，而不是一氧化氮活性的受损。

Alterations in cyclic GMP levels in preeclampsia may reflect increased B-type natriuretic peptide levels and not impaired nitric oxide activity.

机构信息

Núcleo de Pós-Graduação e Pesquisa, Santa Casa de Belo Horizonte, Av. Francisco Sales 1111, Belo Horizonte, MG, Brazil.

出版信息

Clin Biochem. 2011 Aug;44(12):1012-4. doi: 10.1016/j.clinbiochem.2011.05.026. Epub 2011 Jun 13.

DOI:10.1016/j.clinbiochem.2011.05.026
PMID:21683071
Abstract

OBJECTIVES

We compared nitrite, B-type natriuretic peptide (BNP), and cGMP levels in preeclamptic with those found in healthy pregnant.

METHODS

We studied 21 healthy pregnant and 27 preeclamptic. Plasma cGMP and BNP levels were determined by ELISA. Nitrite levels were determined by chemiluminescence.

RESULTS

Higher cGMP and BNP, and lower nitrite levels were found in preeclamptic versus healthy pregnant.

CONCLUSIONS

Altered cGMP levels reflect increased BNP levels and not impaired nitric oxide activity in preeclampsia.

摘要

目的

我们比较了先兆子痫患者和健康孕妇的亚硝酸盐、B 型利钠肽（BNP）和 cGMP 水平。

方法

我们研究了 21 名健康孕妇和 27 名先兆子痫患者。通过 ELISA 测定血浆 cGMP 和 BNP 水平，通过化学发光法测定亚硝酸盐水平。

结果

与健康孕妇相比，先兆子痫患者的 cGMP 和 BNP 水平升高，亚硝酸盐水平降低。

结论

cGMP 水平的改变反映了 BNP 水平的升高，而不是先兆子痫中一氧化氮活性的受损。

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