Lauria M R, Standley C A, Sorokin Y, Todt J C, Bottoms S F, Yelian F D, Cotton D B
Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan, USA.
J Matern Fetal Med. 1996 May-Jun;5(3):128-31. doi: 10.1002/(SICI)1520-6661(199605/06)5:3<128::AID-MFM6>3.0.CO;2-O.
The objective of this study is to determine the possibility that pre-eclampsia, a disease characterized by altered vascular tone, may result in altered levels of fetal BNP and cGMP, and to determine whether pre-eclampsia alters the maternal-fetal relationship of BNP and cGMP. Paired maternal and umbilical venous plasma levels of BNP and cGMP were determined in 13 pre-eclamptic and 9 normotensive primigravidas in the third trimester. Statistical analysis was performed using multivariate analysis of variance, linear regression, and canonical correlation. Overall, levels of cGMP were lower in pre-eclampsia (P < 0.03). Pre-eclampsia was also associated with an altered maternal-fetal relationship for BNP and cGMP (P < 0.008, P < 0.02, respectively). With pre-eclampsia, the maternal:fetal ratio was reduced for BNP and was increased for cGMP. Because of its role as a second messenger for many vasoactive hormones, we hypothesize that fetal cGMP levels may better reflect overall vascular tone than do individual hormones. Altered BNP and cGMP maternal-fetal homeostasis raises the possibility of maternal-fetal coordination of vascular control.
本研究的目的是确定子痫前期（一种以血管张力改变为特征的疾病）是否可能导致胎儿脑钠肽（BNP）和环磷酸鸟苷（cGMP）水平的改变，并确定子痫前期是否会改变母体与胎儿之间BNP和cGMP的关系。对13名单纯性子痫前期患者和9名孕晚期血压正常的初产妇，测定其配对的母体和脐静脉血浆中BNP和cGMP的水平。采用多因素方差分析、线性回归和典型相关分析进行统计学分析。总体而言，子痫前期患者的cGMP水平较低（P<0.03）。子痫前期还与母体与胎儿之间BNP和cGMP的关系改变有关（分别为P<0.008和P<0.02）。子痫前期患者中，BNP的母体与胎儿比值降低，而cGMP的比值升高。由于cGMP作为许多血管活性激素的第二信使，我们推测胎儿cGMP水平可能比单一激素更能反映整体血管张力。母体与胎儿之间BNP和cGMP内环境稳态的改变增加了母体与胎儿血管控制协调的可能性。
