Grussendorf-Conen E I, Giesen M
Department of Dermatology, Medical Faculty, Rhenish-Westphalian Technical University, Aachen, FRG.
Dermatologica. 1990;181(1):11-5. doi: 10.1159/000247851.
We studied 173 biopsies of histologically determined Bowen's disease and looked for the presence of papillomavirus antigen using immunoperoxidase staining. Fifty-nine of the lesions were located at the head, 49 at the extremities, 36 at the trunk and 29 originated from the genital region. Papillomavirus capsid antigen could be clearly identified in 39 (22.5%) cases. Eleven (38%) of the 29 lesions located on genital skin were positive for papillomavirus capsid antigen while 28 (19.4%) of the 144 biopsies from other skin regions contained viral antigen. Our findings are suggestive of an etiologic relationship between the virus and this dermatosis which represents a special variant of squamous cell carcinoma. They indicate that human papillomaviruses may play an important role in the development of cutaneous malignancies.
我们研究了173例经组织学确诊的鲍温病活检标本，并采用免疫过氧化物酶染色法寻找乳头瘤病毒抗原的存在情况。其中59处病变位于头部，49处位于四肢，36处位于躯干，29处起源于生殖器区域。在39例（22.5%）病例中可清晰鉴定出乳头瘤病毒衣壳抗原。位于生殖器皮肤的29处病变中有11处（38%）乳头瘤病毒衣壳抗原呈阳性，而来自其他皮肤区域的144例活检标本中有28例（19.4%）含有病毒抗原。我们的研究结果提示该病毒与这种代表鳞状细胞癌特殊变体的皮肤病之间存在病因学关联。它们表明人乳头瘤病毒可能在皮肤恶性肿瘤的发生发展中起重要作用。
