Centre for Population and Health Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom.
Reprod Biomed Online. 2011 Aug;23(2):204-6. doi: 10.1016/j.rbmo.2011.05.006. Epub 2011 May 19.
The value of anti-müllerian hormone (AMH) as a marker of the ovarian reserve is becoming clear in a range of clinical contexts.This study reports the external validation of a quadratic model-based AMH–age nomogram using a cohort of 15,834 US women. All models previously investigated for the decline in ovarian reserve (i.e. linear, bi-linear, decay curve, power and quadratic models) tended to overestimate AMH by approximately 11% versus the published nomogram, indicating some between-population heterogeneity. Bootstrapping of 1000 datasets indicated that the quadratic model provided the best fit, confirming the choice of this model in the AMH–age nomogram. This nomogram can therefore be used with confidence for the interpretation of AMH in clinical populations.
抗缪勒管激素 (AMH) 作为卵巢储备的标志物在一系列临床情况下的价值逐渐明确。本研究使用 15834 名美国女性的队列报告了基于二次模型的 AMH-年龄列线图的外部验证。之前研究卵巢储备下降的所有模型（即线性、双线性、衰减曲线、幂和二次模型）与公布的列线图相比，都倾向于高估 AMH 约 11%，表明存在一些人群间的异质性。1000 个数据集的自举表明，二次模型提供了最佳拟合，从而确认了该模型在 AMH-年龄列线图中的选择。因此，该列线图可用于临床人群中 AMH 的解读。
