Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA.
Free Radic Biol Med. 2011 Aug 15;51(4):805-12. doi: 10.1016/j.freeradbiomed.2011.05.037. Epub 2011 Jun 16.
Beyond an inert oxidation product of nitric oxide (NO) metabolism, current thinking posits a key role for nitrite as a mediator of NO signaling, especially during hypoxia. This concept has been discussed in the context of nitrite serving a role as an endogenous modulator of NO homeostasis, but also from a novel clinical perspective whereby nitrite therapy may replenish NO signaling and prevent ischemic tissue injury. Indeed, the relatively rapid translation of studies delineating mechanisms of action to ongoing and planned clinical trials has been critical in fuelling interest in nitrite biology, and several excellent reviews have been written on this topic. In this article we limit our discussions to current concepts and what we feel are questions that remain unanswered within the paradigm of nitrite being a mediator of NO biology.
除了一氧化氮（NO）代谢的惰性氧化产物之外，目前的观点还假设亚硝酸盐作为 NO 信号转导的介质发挥关键作用，尤其是在缺氧期间。这一概念在亚硝酸盐作为 NO 动态平衡的内源性调节剂发挥作用的背景下进行了讨论，但也从一个新的临床角度进行了讨论，即亚硝酸盐治疗可能会补充 NO 信号转导并预防缺血组织损伤。事实上，将阐明作用机制的研究迅速转化为正在进行和计划中的临床试验，对于激发人们对亚硝酸盐生物学的兴趣至关重要，并且已经就这一主题撰写了几篇优秀的评论文章。在本文中，我们将讨论仅限于当前的概念，以及我们认为在亚硝酸盐作为 NO 生物学介质的范例中仍然存在的未解决的问题。
