生物学、营养学与治疗学中的硝酸盐和亚硝酸盐
Nitrate and nitrite in biology, nutrition and therapeutics.
作者信息
Lundberg Jon O, Gladwin Mark T, Ahluwalia Amrita, Benjamin Nigel, Bryan Nathan S, Butler Anthony, Cabrales Pedro, Fago Angela, Feelisch Martin, Ford Peter C, Freeman Bruce A, Frenneaux Michael, Friedman Joel, Kelm Malte, Kevil Christopher G, Kim-Shapiro Daniel B, Kozlov Andrey V, Lancaster Jack R, Lefer David J, McColl Kenneth, McCurry Kenneth, Patel Rakesh P, Petersson Joel, Rassaf Tienush, Reutov Valentin P, Richter-Addo George B, Schechter Alan, Shiva Sruti, Tsuchiya Koichiro, van Faassen Ernst E, Webb Andrew J, Zuckerbraun Brian S, Zweier Jay L, Weitzberg Eddie
机构信息
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
出版信息
Nat Chem Biol. 2009 Dec;5(12):865-9. doi: 10.1038/nchembio.260.
Abstract
Inorganic nitrate and nitrite from endogenous or dietary sources are metabolized in vivo to nitric oxide (NO) and other bioactive nitrogen oxides. The nitrate-nitrite-NO pathway is emerging as an important mediator of blood flow regulation, cell signaling, energetics and tissue responses to hypoxia. The latest advances in our understanding of the biochemistry, physiology and therapeutics of nitrate, nitrite and NO were discussed during a recent 2-day meeting at the Nobel Forum, Karolinska Institutet in Stockholm.
摘要
内源性或膳食来源的无机硝酸盐和亚硝酸盐在体内代谢为一氧化氮（NO）和其他生物活性氮氧化物。硝酸盐-亚硝酸盐-NO途径正逐渐成为血流调节、细胞信号传导、能量代谢以及组织对缺氧反应的重要介质。最近在斯德哥尔摩卡罗林斯卡学院诺贝尔论坛举行为期两天的会议，会上讨论了我们在硝酸盐、亚硝酸盐和NO的生物化学、生理学及治疗学方面的最新进展。
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