Department of Obstetrics, Sao Paulo Federal University, Sao Paulo, Brazil.
J Reprod Immunol. 2011 Jun;90(1):111-6. doi: 10.1016/j.jri.2011.04.008.
The incidence of gestational diabetes (GD) is rising worldwide, in parallel with obesity and type 2 diabetes. Obesity and GD are conditions that have in common a state of chronic, low-grade subclinical inflammation characterized by abnormal production of cytokines and mediators. Genetic polymorphisms may influence the production of inflammatory mediators and predispose to different disorders, including diabetes. The aim of this study was to review the existing literature on the relationship between inflammatory mediator gene polymorphisms and GD. The search in PubMed was restricted to articles published in English, from January 1990 to December 2010. Eight studies were included. These publications evaluated 13 different SNPs and six inflammatory mediators in the blood of women with GD. Gene polymorphisms related to leptin, mannose-binding lectin (MBL) and RAGE (receptor for advanced glycation end products) were individually evaluated in a single study each. Leptin and MBL plasma levels were also evaluated in two studies. The participants included in the studies were ethnically different, but matched with controls. Different criteria were adopted to select the participants. Seven of the eight studies included took into consideration the BMI of patients and controls. Due to the heterogeneity and limited number of studies on GD and inflammatory gene polymorphisms, we could not pool together any of the results or perform any additional analyses of the existing data. Since the existing findings come from isolated studies with mostly small sample sizes, there is a need for new, larger, properly designed studies of good methodological quality.
妊娠期糖尿病（gestational diabetes mellitus，GDM）的发病率在全球范围内呈上升趋势，与肥胖和 2 型糖尿病的发病率平行上升。肥胖和 GDM 都存在慢性、低度亚临床炎症状态，其特征是细胞因子和介质的异常产生。遗传多态性可能会影响炎症介质的产生，并导致不同的疾病，包括糖尿病。本研究旨在综述炎症介质基因多态性与 GDM 之间关系的现有文献。在 PubMed 中进行的检索限定于 1990 年 1 月至 2010 年 12 月发表的英文文献。共纳入 8 项研究。这些出版物评估了 8 项研究中 GDM 妇女血液中 13 种不同的 SNP 和 6 种炎症介质。每种基因多态性分别在一项研究中评估了与瘦素、甘露糖结合凝集素（mannose-binding lectin，MBL）和晚期糖基化终产物受体（receptor for advanced glycation end products，RAGE）相关的 SNP。有两项研究还评估了瘦素和 MBL 的血浆水平。纳入的研究参与者具有不同的种族，但与对照组相匹配。不同的研究采用了不同的标准来选择参与者。8 项研究中有 7 项考虑了患者和对照组的 BMI。由于 GDM 和炎症基因多态性的研究数量有限且存在异质性，我们无法对任何结果进行汇总，也无法对现有数据进行任何额外分析。由于现有研究结果来自于样本量较小的孤立研究，因此需要开展更多新的、更大规模、设计良好的、具有高质量方法学的研究。
