Departamento de Fisioterapia da Escola de Educacao Fisica, Fisioterapia e Terapia Ocupacional, Universidade Federal de Minas Gerais, Avenida Antonio Carlos, 6627 Pampulha, 31270-901 Belo Horizonte, Minas Gerais, Brazil.
Arch Gerontol Geriatr. 2012 May-Jun;54(3):415-20. doi: 10.1016/j.archger.2011.05.014. Epub 2011 Jun 17.
Biomarkers are important factors in the identification of the frail elderly (higher risk of developing disease) and in assessing the impact of PTI. On the other hand, BDNF has been related to neuroprotection in a series of central nervous system diseases in older age. The levels of BDNF in groups of elderly women classified according to Fried phenotype (non-frail and pre-frail) were compared. We assessed the impact of a PTI on BDNF levels. A convenience sample of 48 elderly women was randomly selected. The PTI group was composed by 20 elderly women selected from this group. Plasma neurotrophic factors, such as BDNF, glial-derived neutrophic factor (GDNF), and nerve growth factor (NGF) were measured by enzyme-linked immunosorbent assay (ELISA). Timed-up-and-go (TUG) test, hand-grip and work/body weight were evaluated before and after the intervention. Plasma concentrations of BDNF were significantly higher in non-frail in comparison to pre-frail elderly women. After the PTI, higher levels of BDNF were found in elderly women (before 351±68 pg/ml and after 593±79 pg/ml; p<0.001). Both groups had an increase in BDNF levels after the PTI. The low levels of BDNF in pre-frail elderly women suggest that this neurotrophic factor may be a key pathophysiological mediator in the syndrome of frailty. The fact that PTI increased BDNF levels in both groups suggests that it may be possible to modify this phenotype.
生物标志物是识别体弱老年人（患病风险较高）和评估 PTI 影响的重要因素。另一方面，BDNF 与老年人一系列中枢神经系统疾病的神经保护有关。比较了根据 Fried 表型（非虚弱和虚弱前期）分类的老年女性组的 BDNF 水平。我们评估了 PTI 对 BDNF 水平的影响。随机选择了 48 名老年女性的方便样本。PTI 组由从该组中选择的 20 名老年女性组成。通过酶联免疫吸附测定（ELISA）测量了 BDNF 等神经营养因子、胶质衍生神经营养因子（GDNF）和神经生长因子（NGF）。在干预前后评估了计时起立行走（TUG）测试、握力和工作/体重。与虚弱前期老年人相比，非虚弱老年人的 BDNF 血浆浓度明显更高。PTI 后，老年女性的 BDNF 水平升高（之前为 351±68 pg/ml，之后为 593±79 pg/ml；p<0.001）。两组 PTI 后 BDNF 水平均升高。虚弱前期老年女性 BDNF 水平较低表明，这种神经营养因子可能是虚弱综合征的关键病理生理介质。PTI 增加了两组的 BDNF 水平，这表明可能有可能改变这种表型。
