Whitmire C E
J Natl Cancer Inst. 1979 Mar;62(3):555-9. doi: 10.1093/jnci/62.3.555.
The effects of sc administration of 3-methylcholanthrene (MCA), 7,12-dimethylbenz[a]anthracene (DMBA), and benzo[a]pyrene (BP) on spontaneous viral leukemia and subcutaneous sarcoma induction have been studied in weanling C58/J mice. MCA produced significantly more sarcomas at the inoculation site than did DMBA or BP; moreover, it interfered with leukemia development. DMBA produced fewer sarcomas, and the incidence of leukemia was comparable to that found in the controls. BP accelerated the incidence of leukemia, although no sarcomas were produced. When the effect of the age of the mice at the time of MCA treatment on the incidence of leukemia and sarcomas was studied, newborn and weanling mice were found to develop primarily sarcomas, whereas no sarcomas were produced in the 16-week-old mice, and 52-64% of the 16-week-old mice developed leukemia. The reason no sarcomas were found in the C58 mice was apparently different from the reason no sarcomas were found in AKR mice, inasmuch as the AKR mice did not live long enough for sarcomas to develop. Immunologic surveillance may have played a part in the sarcoma suppression in the C58 mouse.
在断乳期的C58/J小鼠中，研究了皮下注射3-甲基胆蒽（MCA）、7,12-二甲基苯并[a]蒽（DMBA）和苯并[a]芘（BP）对自发性病毒性白血病和皮下肉瘤诱导的影响。与DMBA或BP相比，MCA在接种部位产生的肉瘤明显更多；此外，它还干扰白血病的发展。DMBA产生的肉瘤较少，白血病发病率与对照组相当。BP加速了白血病的发病率，尽管未产生肉瘤。当研究MCA处理时小鼠年龄对白血病和肉瘤发病率的影响时，发现新生和断乳期小鼠主要发生肉瘤，而16周龄小鼠未产生肉瘤，且16周龄小鼠中有52 - 64%发生白血病。在C58小鼠中未发现肉瘤的原因显然与在AKR小鼠中未发现肉瘤的原因不同，因为AKR小鼠存活时间不够长，肉瘤无法发展。免疫监视可能在C58小鼠的肉瘤抑制中起了作用。
