Department of Histopathology, Royal Marsden Hospital, London, UK.
Ann Diagn Pathol. 2012 Oct;16(5):407-10. doi: 10.1016/j.anndiagpath.2011.04.001. Epub 2011 Jun 17.
Mucinous tubular and spindle cell carcinoma (MTSCC) is a rare, distinctive renal neoplasm characterized by an admixture of cuboidal cells in tubules and sheets of spindle cells, typically with low-grade nuclei and a myxoid or mucinous background. It is characteristically of low malignant potential, and only rare metastatic cases have been reported. We describe a case in which the patient presented with extensive regional and distant metastases, but both primary and metastatic tumor showed the typical histomorphology of bland cuboidal or spindle cells lacking pleomorphism, mitoses, and necrosis. Almost all previous cases of metastatic MTSCCs have shown nuclear atypia or sarcomatoid morphology of the primary tumor; and metastatic renal MTSCC in which the primary neoplasm does not display atypical features is exceptional, serving to highlight that these rare tumors can behave aggressively even with "indolent" histological appearances.
黏液性管状和梭形细胞癌（MTSCC）是一种罕见的、独特的肾肿瘤，其特征是在管状和梭形细胞片中混合有立方细胞，通常具有低级别核和黏液样或黏液性背景。它的恶性潜能通常较低，仅有少数转移性病例被报道。我们描述了一例患者表现为广泛的区域性和远处转移，但原发性和转移性肿瘤均显示出典型的形态学特征，即无明显异型性的立方细胞或梭形细胞，无有丝分裂和坏死。几乎所有先前的转移性 MTSCC 病例均显示原发性肿瘤的核异型性或肉瘤样形态；而原发性肿瘤不显示非典型特征的转移性肾 MTSCC 则较为罕见，这突出表明这些罕见的肿瘤即使具有“惰性”组织学表现也可能具有侵袭性。
