From the Department of Pathology, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, India.
Arch Pathol Lab Med. 2020 Jan;144(1):115-118. doi: 10.5858/arpa.2017-0506-RS. Epub 2019 Mar 13.
Mucinous tubular and spindle cell carcinomas are rare kidney tumors with generally indolent behavior. As the name suggests, classic histomorphology reveals bland spindle cells, tubules, and mucinous stroma. Uncommon histologic features include mucin-poor stroma, high nuclear grade, cellular pleomorphism, and presence of necrosis. Rare cases can show aggressive growth and distant metastasis. Mucinous tubular and spindle cell carcinoma has characteristic chromosomal abnormalities and the molecular signature remains the same, irrespective of the varied histomorphology.
黏液性管状和梭形细胞癌是一种罕见的肾脏肿瘤，通常具有惰性行为。顾名思义，经典的组织形态学显示出温和的梭形细胞、管状和黏液性基质。罕见的组织学特征包括黏液性基质减少、核分级高、细胞多形性和坏死存在。罕见的病例可表现为侵袭性生长和远处转移。黏液性管状和梭形细胞癌具有特征性的染色体异常，并且分子特征保持不变，与不同的组织形态学无关。
