2-苯并咪唑并[1,2-b]哒嗪衍生物对捻转血矛线虫具有高活性。
2-Phenylimidazo[1,2-b]pyridazine derivatives highly active against Haemonchus contortus.
机构信息
CSIRO Materials Science and Engineering, Bayview Avenue, Clayton, VIC 3168, Australia.
出版信息
Bioorg Med Chem Lett. 2011 Jul 15;21(14):4160-3. doi: 10.1016/j.bmcl.2011.05.096. Epub 2011 Jun 1.
PMID:21684739
Abstract
A series of 2-phenylimidazo[1,2-b]pyridazine derivatives were synthesized and evaluated for their in vitro anthelmintic activity against Haemonchus contortus. The most active compounds had in vitro LD(99) values of 30nM, which is comparable to that of the benchmark commercial nematocide, Ivermectin.
摘要
一系列 2-苯基咪唑并[1,2-b]哒嗪衍生物被合成并评估了它们对捻转血矛线虫的体外驱虫活性。最活跃的化合物在体外 LD(99)值为 30nM，与基准商业驱虫药伊维菌素相当。
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