Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra Ranchi-835215, Jharkhand, India.
Acta Pharm. 2011 Jun;61(2):187-201. doi: 10.2478/v10007-011-0018-2.
A series of 1-(2-methyl-4-nitro-imidazol-1-yl)-3-arylaminopropan-2-ones (2a-e), 2-methyl-5-nitro-1-{2-[arylmethoxy]ethyl}-1H-imidazoles (5a-d), and N-(3-hydroxyphenyl)-2-(substituted imidazol-1-yl)alkanamides (8a-e) were synthesized with the aim to develop novel imidazole analogs with broad-spectrum chemotherapeutic properties. Title compounds were evaluated for their anti-HIV and antibacterial activities.
一系列 1-(2-甲基-4-硝基-1H-咪唑-1-基)-3-(芳基氨基)丙-2-酮（2a-e）、2-甲基-5-硝基-1-{2-[芳基甲氧基]乙基}-1H-咪唑（5a-d）和 N-(3-羟基苯基)-2-（取代咪唑-1-基）烷酰胺（8a-e）被合成，目的是开发具有广谱化疗特性的新型咪唑类似物。标题化合物被评估了它们的抗 HIV 和抗菌活性。
