Yamada K
Laboratory for Pharmaceutical Education, Tokyo College of Pharmacy, Japan.
Res Commun Chem Pathol Pharmacol. 1990 Aug;69(2):241-4.
Effect of a ten-day melatonin treatment on adrenal function in male rats was studied. The weight of adrenal gland was decreased by treatments with the highest dose of melatonin (30 mg/kg, s.c., injection time: 1700) once daily for ten days. And also corticosterone levels in adrenal gland and in serum were significantly decreased. Lower doses (1, 5 and 15 mg/kg) had no effect. The increase of corticosterone levels in adrenal gland by successive treatments with ACTH, were suppressed by simultaneous injections of melatonin. On the other hand, after dexamethasone, the increase in corticosterone levels induced by ACTH were also suppressed by melatonin treatment. These results suggest that melatonin may have an inhibitory action on the effect of ACTH on rat adrenal gland.
研究了为期十天的褪黑素治疗对雄性大鼠肾上腺功能的影响。连续十天每天一次皮下注射最高剂量的褪黑素（30毫克/千克，注射时间：17:00）可使肾上腺重量减轻。肾上腺和血清中的皮质酮水平也显著降低。较低剂量（1、5和15毫克/千克）则无此作用。促肾上腺皮质激素连续处理引起的肾上腺皮质酮水平升高，会被同时注射的褪黑素所抑制。另一方面，地塞米松处理后，促肾上腺皮质激素诱导的皮质酮水平升高也会被褪黑素治疗所抑制。这些结果表明，褪黑素可能对促肾上腺皮质激素对大鼠肾上腺的作用具有抑制作用。
