Mori W, Aoyama H, Mori N
Jpn J Exp Med. 1984 Dec;54(6):255-61.
Administration of the pineal hormone melatonin (1 mg/day) to growing female rats provided significant protection against the injurious effects (decrease of body weight gain and atrophy of the thymus and adrenals) caused by a glucocorticoid, dexamethasone (0.4-0.01 mg/day). The protective effects were greater at lower doses of dexamethasone, and the adrenal/body weight ratio was well maintained. Histological examination of the thymus and adrenals confirmed both the injurious effect of dexamethasone and the protective effect of melatonin. Dexamethasone also increased glutamic pyruvic transaminase, free fatty acid, triglyceride and glucose in the serum, and melatonin significantly reduced the former two changes. It is proposed that the protection afforded by the pineal hormone melatonin against the injurious effects of dexamethasone is due to a direct anti-glucocorticoid action and dose not involve any other endocrine organ.
给生长中的雌性大鼠注射松果体激素褪黑素（1毫克/天），可显著保护其免受糖皮质激素地塞米松（0.4 - 0.01毫克/天）造成的有害影响（体重增加减少以及胸腺和肾上腺萎缩）。在地塞米松剂量较低时，保护作用更强，且肾上腺/体重比得到良好维持。对胸腺和肾上腺的组织学检查证实了地塞米松的有害作用以及褪黑素的保护作用。地塞米松还会使血清中的谷丙转氨酶、游离脂肪酸、甘油三酯和葡萄糖升高，而褪黑素可显著减轻前两种变化。有人提出，松果体激素褪黑素对地塞米松有害作用的保护是由于直接的抗糖皮质激素作用，且不涉及任何其他内分泌器官。
