Ionov A Iu, Fisher A A, Shubich M G
Ter Arkh. 1990;62(5):51-5.
Alkaline phosphatase (AP), acid phosphatase and myeloperoxidase (MP) activity and the level of cation protein (CP) in blood and synovial fluid (SF) neutrophils were studied and compared in 54 patients with rheumatoid arthritis (RA) and in 22 patients suffering from primary osteoarthrosis deformans (OAD) combined with reactive synovitis. As compared to the patients with OAD, the patients with RA manifested a significant rise of AP, acid phosphatase and MP activity together with a decrease of the level of CP in blood neutrophils. Meanwhile in SF neutrophils from the patients with RA, all the parameters appeared higher than in OAD and were lower that in blood neutrophils in both the groups. As compared to the routine biochemical and cytological tests, the diagnostic information content of the cytochemical parameters of blood neutrophils (AP, acid phosphatase) and SF neutrophils (AP, acid phosphatase, MP) from the patients with RA (against the patients suffering from OAD) was noticeably higher.
对54例类风湿性关节炎（RA）患者和22例患有原发性变形性骨关节炎（OAD）合并反应性滑膜炎的患者，研究并比较了其血液及滑液（SF）中性粒细胞中的碱性磷酸酶（AP）、酸性磷酸酶和髓过氧化物酶（MP）活性以及阳离子蛋白（CP）水平。与OAD患者相比，RA患者血液中性粒细胞中的AP、酸性磷酸酶和MP活性显著升高，同时CP水平降低。与此同时，RA患者SF中性粒细胞中的所有参数均高于OAD患者，且两组中均低于血液中性粒细胞中的参数。与常规生化和细胞学检查相比，RA患者（相对于OAD患者）血液中性粒细胞（AP、酸性磷酸酶）和SF中性粒细胞（AP、酸性磷酸酶、MP）的细胞化学参数的诊断信息量明显更高。
