Zakharova M M, Alekberova Z S, Trofimova T M, Riazantseva T A
Ter Arkh. 1988;60(7):79-84.
A comparative study of the synovial fluid (SF) composition was conducted in 72 patients with rheumatoid arthritis (RA) with relation to the presence of the rheumatoid factor (RF) and clinical manifestations of this disease. A statistically significant difference in the SF composition (the number of leukocytes, neutrophils and ragocytes) was shown in seropositive and seronegative RA. The content of total protein and glucose in SF did not practically differ in both cases. In the common group of the RA patients correlation was established between the number of neutrophils, the level of total protein, percentage of ragocytes, the level of complement in SF and a degree of general inflammatory activity of disease. A subgroup of RA patients (32%) was identified with the prevalence of lymphocytes, a slight rise of the level of total protein, a low percentage of ragocytes and rather a high level of complement. In 87% of the above patients noticeable osteochondrous destruction (III-IV roentgenological stage) was noted against a background of low inflammatory activity. The data obtained confirmed an important role of SF investigation for the elucidation of the mechanisms of pathogenesis, differential diagnosis and prognosis.
对72例类风湿性关节炎（RA）患者的滑液（SF）成分进行了一项比较研究，该研究与类风湿因子（RF）的存在及该疾病的临床表现有关。血清阳性和血清阴性RA患者的滑液成分（白细胞、中性粒细胞和类风湿细胞数量）存在统计学上的显著差异。两种情况下，滑液中总蛋白和葡萄糖的含量实际上并无差异。在类风湿性关节炎患者的普通组中，中性粒细胞数量、总蛋白水平、类风湿细胞百分比、滑液中补体水平与疾病的总体炎症活动程度之间建立了相关性。确定了一个类风湿性关节炎患者亚组（32%），其淋巴细胞占优势，总蛋白水平略有升高，类风湿细胞百分比低，补体水平相当高。在上述患者中，87%在低炎症活动背景下出现明显的骨软骨破坏（放射学III - IV期）。获得的数据证实了滑液检查在阐明发病机制、鉴别诊断和预后方面的重要作用。
