Farmer T G, Edgar T F, Peppas N A
Department of Chemical, The University of Texas at Austin, 1 University Station C0400, Austin, TX 78712-0231, USA.
J Drug Deliv Sci Technol. 2008 Nov;18(6):387-391. doi: 10.1016/s1773-2247(08)50076-1.
A pharmacokinetic model is proposed to describe the glucoregulatory process. The model describes the dynamics of glucose, amino acids, and fatty acids, as well as both the hormonal actions and dynamics of insulin, glucagon, epinephrine, and glucagon-like peptide-one. The model was developed assuming that the dynamics of each species occurrs in only one compartment. Several forms of the metabolic absorption and elimination rates, along with possibilities for increasing the complexity of each compartmental model are discussed. Once properly identified and validated, the novel model has the potential to be more descriptive than other models describing glucose dynamics in the body.
提出了一种药代动力学模型来描述葡萄糖调节过程。该模型描述了葡萄糖、氨基酸和脂肪酸的动态变化，以及胰岛素、胰高血糖素、肾上腺素和胰高血糖素样肽-1的激素作用和动态变化。该模型是在假设每个物种的动态变化仅发生在一个隔室的情况下开发的。讨论了几种代谢吸收和消除速率的形式，以及增加每个隔室模型复杂性的可能性。一旦经过适当识别和验证，这个新模型有可能比其他描述体内葡萄糖动态变化的模型更具描述性。
