血管周围脂肪组织与血管疾病
Perivascular adipose tissue and vascular disease.
作者信息
Britton Kathryn A, Fox Caroline S
机构信息
National Heart, Lung & Blood Institute's Framingham Heart Study, Framingham, MA, USA.
出版信息
Clin Lipidol. 2011 Feb;6(1):79-91. doi: 10.2217/clp.10.89.
Abstract
Perivascular adipose tissue is a local deposit of adipose tissue surrounding the vasculature. Perivascular adipose tissue is present throughout the body and has been shown to have a local effect on blood vessels. The influence of perivascular adipose tissue on the vasculature changes with increasing adiposity. This article describes the anatomy and pathophysiology of perivascular adipose tissue and the experimental evidence supporting its local adverse effect on the vasculature. Methods for quantifying perivascular adipose tissue in free-living populations will be described. Finally, the epidemiological literature demonstrating an association between perivascular adipose tissue and cardiometabolic disease will be explored.
摘要
血管周围脂肪组织是围绕血管系统的局部脂肪组织沉积。血管周围脂肪组织遍布全身，并已显示出对血管有局部影响。随着肥胖程度的增加，血管周围脂肪组织对血管系统的影响会发生变化。本文描述了血管周围脂肪组织的解剖学和病理生理学，以及支持其对血管系统产生局部不良影响的实验证据。还将介绍在自由生活人群中量化血管周围脂肪组织的方法。最后，将探讨表明血管周围脂肪组织与心脏代谢疾病之间存在关联的流行病学文献。
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