Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Box 281, SE-171 77 Stockholm, Sweden.
J Clin Endocrinol Metab. 2010 Jun;95(6):2927-34. doi: 10.1210/jc.2009-2685. Epub 2010 Apr 7.
Some previous studies have reported an association between circulating adiponectin and selected measures of vascular function and morphology, but most of these studies have been performed in small samples of patients with preexisting disease.
We aimed to evaluate associations between circulating adiponectin and comprehensive measures of vascular function and morphology in a large sample of individuals from the community.
DESIGN, SETTINGS, AND PARTICIPANTS: We conducted a cross-sectional investigation of 981 70-yr-old participants (50% women) of the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS).
Measures of outcome included vascular function [common carotid artery (CCA) distensibility, flow-mediated dilation, endothelium-dependent and endothelium-independent vasodilation using invasive methods] and vascular morphology [intima-media (IM) thickness, plaque presence, gray scale median (GSM) in the IM and plaques].
In age- and sex-adjusted models, adiponectin was positively associated with IM-GSM, plaque GSM, CCA distensibility, endothelium-dependent and endothelium-independent vasodilation. In multivariable models (with additional adjustment for body mass index; systolic blood pressure; antihypertensive, antidiabetic, and lipid-lowering medication; fasting blood glucose; total cholesterol; high-density lipoprotein cholesterol; creatinine; and smoking), adiponectin remained positively associated with IM-GSM [beta = 2.06; 95% confidence interval (CI), 0.54, 3.58], plaque GSM (beta = 3.11; 95% CI, 0.36, 5.86), and CCA distensibility (beta = 0.04; 95% CI, 0.00, 0.07).
Serum levels of adiponectin were positively associated with IM-GSM and plaque GSM (indicating lower fat content in the IM and plaques) and CCA distensibility (indicating higher wall elasticity), independent of potential confounders. Our results imply that adiponectin is associated with less arterial pathology.
一些先前的研究报告了循环脂联素与血管功能和形态的某些指标之间的关联，但这些研究大多是在患有预先存在疾病的小样本患者中进行的。
我们旨在评估在社区中大量个体中循环脂联素与血管功能和形态综合指标之间的关联。
设计、设置和参与者：我们对前瞻性血管研究中的乌普萨拉老年人（PIVUS）的 981 名 70 岁参与者（50%为女性）进行了横断面调查。
包括血管功能[颈总动脉（CCA）可扩张性、血流介导的扩张、使用侵入性方法的内皮依赖性和非依赖性血管扩张]和血管形态[内膜-中膜（IM）厚度、斑块存在、IM 中的灰度中位数（GSM）和斑块]的观察指标。
在年龄和性别调整模型中，脂联素与 IM-GSM、斑块 GSM、CCA 可扩张性、内皮依赖性和非依赖性血管扩张呈正相关。在多变量模型中（进一步调整体重指数、收缩压、抗高血压、抗糖尿病和降脂药物、空腹血糖、总胆固醇、高密度脂蛋白胆固醇、肌酐和吸烟），脂联素与 IM-GSM[β=2.06；95%置信区间（CI），0.54，3.58]、斑块 GSM（β=3.11；95%CI，0.36，5.86）和 CCA 可扩张性（β=0.04；95%CI，0.00，0.07）仍呈正相关。
血清脂联素水平与 IM-GSM 和斑块 GSM（表明 IM 和斑块中的脂肪含量较低）和 CCA 可扩张性（表明壁弹性较高）呈正相关，与潜在混杂因素无关。我们的结果表明，脂联素与较少的动脉病理学有关。
