真核生物翻译控制中，真核起始因子5（eIF5）是一种具有双重功能的GAP和GDI。
eIF5 is a dual function GAP and GDI for eukaryotic translational control.
作者信息
Jennings Martin D, Pavitt Graham D
机构信息
Faculty of Life Sciences; The University of Manchester; Manchester UK.
出版信息
Small GTPases. 2010 Sep;1(2):118-123. doi: 10.4161/sgtp.1.2.13783.
Abstract
We recently showed in a publication in Nature that the eukaryotic translation initiation factor eIF5 has a second regulatory function and is a GDI (GDP dissociation inhibitor) in addition to its previously characterized role as a GAP (GTPase accelerating protein). These findings provide new insight into the mechanism of translation initiation in eukaryotic cells. Additional findings show that the GDI function is critical for the normal regulation of protein synthesis by phosphorylation of eIF2α at ser51. Because eIF2 phosphorylation is a ubiquitous mode of translational control these results are of broad interest. Here we review these and related studies and suggest they offer further evidence of parallels between the functions of regulators of the translation factor eIF 2 and both heterotrimeric and small GTPases.
摘要
我们最近在《自然》杂志上发表的一篇论文中指出，真核生物翻译起始因子eIF5除了其先前已被描述的作为GAP（GTP酶加速蛋白）的作用外，还具有第二种调节功能，并且是一种GDI（GDP解离抑制剂）。这些发现为真核细胞中翻译起始的机制提供了新的见解。其他研究结果表明，GDI功能对于通过ser51位点的eIF2α磷酸化来正常调节蛋白质合成至关重要。由于eIF2磷酸化是翻译控制的一种普遍模式，因此这些结果具有广泛的意义。在这里，我们综述这些以及相关研究，并表明它们进一步证明了翻译因子eIF 2的调节因子的功能与异源三聚体GTP酶和小GTP酶之间存在相似之处。
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eIF5 is a dual function GAP and GDI for eukaryotic translational control.真核生物翻译控制中，真核起始因子5（eIF5）是一种具有双重功能的GAP和GDI。
Small GTPases. 2010 Sep;1(2):118-123. doi: 10.4161/sgtp.1.2.13783.
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本文引用的文献
1
eIF5 has GDI activity necessary for translational control by eIF2 phosphorylation.真核起始因子5（eIF5）具有鸟嘌呤核苷酸解离抑制剂（GDI）活性，这是eIF2磷酸化进行翻译控制所必需的。
Nature. 2010 May 20;465(7296):378-81. doi: 10.1038/nature09003.
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Molecular view of 43 S complex formation and start site selection in eukaryotic translation initiation.真核生物翻译起始中43 S复合物形成及起始位点选择的分子观点。
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The mechanism of eukaryotic translation initiation and principles of its regulation.真核生物翻译起始的机制与调控原则。
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Protein synthesis and its control in neuronal cells with a focus on vanishing white matter disease.蛋白质合成及其在神经元细胞中的调控——以进行性脑白质病为例。
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Eukaryotic and archaeal translation initiation factor 2: a heterotrimeric tRNA carrier.真核生物和古细菌翻译起始因子2：一种异源三聚体tRNA载体。
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eIF1 controls multiple steps in start codon recognition during eukaryotic translation initiation.真核生物翻译起始过程中，真核起始因子1（eIF1）控制起始密码子识别的多个步骤。
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Archaeal aIF2B interacts with eukaryotic translation initiation factors eIF2alpha and eIF2Balpha: Implications for aIF2B function and eIF2B regulation.古菌aIF2B与真核生物翻译起始因子eIF2α和eIF2Bα相互作用：对aIF2B功能和eIF2B调节的影响。
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