Kawauchi Takeshi
Department of Anatomy; Keio University School of Medicine; Tokyo, Japan.
Small GTPases. 2011 Jan;2(1):36-40. doi: 10.4161/sgtp.2.1.15001.
Accumulating evidence indicate that Rho family small GTPases, including RhoA, Rac1 and Cdc42, control cytoskeletal organization and cell adhesion, and thereby cell migration in vitro and in vivo. Recently, the involvement of other small GTPases, such as Rab and Arf family proteins in cell migration has also been evaluated. Rab5, Rab11 and Rab7, which regulate endocytosis, recycling and lysosomal degradation pathways, respectively, are shown to have essential roles in the migration of immature neurons during the development of cerebral cortex in vivo. These Rab proteins control distinct steps of neuronal migration through the regulation of N-cadherin-mediated cell adhesion. In this extra view paper, I will discuss the functions of Rho and Rab family small GTP ases in cell migration with particular focus on the migrating neurons in the developing cerebral cortex.
越来越多的证据表明，包括RhoA、Rac1和Cdc42在内的Rho家族小GTP酶控制细胞骨架组织和细胞黏附，从而在体外和体内控制细胞迁移。最近，其他小GTP酶，如Rab和Arf家族蛋白在细胞迁移中的作用也得到了评估。分别调节内吞作用、再循环和溶酶体降解途径的Rab5、Rab11和Rab7，在体内大脑皮质发育过程中未成熟神经元的迁移中发挥着重要作用。这些Rab蛋白通过调节N-钙黏蛋白介导的细胞黏附来控制神经元迁移的不同步骤。在这篇额外观点论文中，我将讨论Rho和Rab家族小GTP酶在细胞迁移中的功能，特别关注发育中的大脑皮质中的迁移神经元。
