Satake Yoshiyuki, Shimmura Shigeto, Shimazaki Jun
Tokyo Dental College, Ophthalmology, 5-11-13 Sugano, Ichikawa, Chiba, 272-8513, Japan.
BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.11.2008.1239. Epub 2009 Apr 14.
We report the clinical outcome of cultivated autologous limbal epithelial transplantation for symptomatic bullous keratopathy in an 87-year-old female patient presenting with recurrent corneal erosion and intractable ocular pain. The patient refused corneal transplantation, and transplantation of a cultivated autologous limbal epithelial sheet was carried out to free her of the symptoms associated with chronic pseudophakic bullous keratopathy. Both integrity of transplanted epithelium and relief from intolerable ocular pain were achieved and maintained immediately after surgery. No complications were noted in either the transplanted eye or donor eye during the 43-month follow-up period. Our findings support that patients with bullous keratopathy not consenting to procedures to improve visual acuity in whom the primary aim is relief of symptoms may benefit from cultivated autologous limbal epithelial transplantation.
我们报告了一位87岁女性患者，因复发性角膜糜烂和顽固性眼痛，接受自体培养角膜缘上皮移植治疗症状性大疱性角膜病变的临床结果。该患者拒绝角膜移植，遂进行自体培养角膜缘上皮片移植，以消除与慢性人工晶状体大疱性角膜病变相关的症状。术后立即实现并维持了移植上皮的完整性，且患者无法忍受的眼痛得到缓解。在43个月的随访期内，移植眼和供体眼均未出现并发症。我们的研究结果表明，对于那些不同意改善视力手术，主要目的是缓解症状的大疱性角膜病变患者，自体培养角膜缘上皮移植可能有益。
