Xiao Ping, Xue Ling, Peng Jian-Jun, Feng Shi-Ting, Liao Bing, Wen Jian-Ming
The First Affiliated Hospital, Sun Yat-Sen University, Department of Pathology, 58 Zhongshan 2nd Road, Guangzhou, 510080, China.
BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.11.2008.1200. Epub 2009 Apr 7.
A rare case of intrasellar mixed gangliocytoma-adenoma including ependymal component, which presented clinically with acromegaly and menstrual disorder, is described here. The tumour was totally removed via trans-sphenoidal surgery. A histological examination of the resected specimen showed that the tumour was composed of ganglion cells, adenomatous cells and ependymal cells. Most intrasellar gangliocytomas are composed of two components: adenomatous cells and ganglion cells. In this case, in addition to mixed adenomatous and ganglion cells, focal ependymal cells forming small cysts were found. Based on these histopathological findings, it was inferred that stem cells existed in the pituitary gland during embryonic development. The stem cells were able to differentiate into three directions: ganglion cells, adenomatous cells and ependymal cells, and as a result an intrasellar mixed gangliocyto-adenoma including ependymal component developed.
本文描述了一例罕见的鞍内混合性神经节细胞瘤-腺瘤，其中包含室管膜成分，临床表现为肢端肥大症和月经紊乱。该肿瘤通过经蝶窦手术被完全切除。对切除标本的组织学检查显示，肿瘤由神经节细胞、腺瘤细胞和室管膜细胞组成。大多数鞍内神经节细胞瘤由两种成分组成：腺瘤细胞和神经节细胞。在该病例中，除了混合的腺瘤细胞和神经节细胞外，还发现了形成小囊肿的局灶性室管膜细胞。基于这些组织病理学发现，推测胚胎发育期间垂体中存在干细胞。这些干细胞能够向三个方向分化：神经节细胞、腺瘤细胞和室管膜细胞，结果形成了包含室管膜成分的鞍内混合性神经节细胞瘤-腺瘤。
