Kamel O W, Horoupian D S, Silverberg G D
Department of Pathology, Stanford University Hospital, CA 94305.
Hum Pathol. 1989 Dec;20(12):1198-203. doi: 10.1016/s0046-8177(89)80012-7.
A mixed gangliocytoma-adenoma occurring in the pituitary fossa of a patient who presented with acromegaly, galactorrhea, and headaches is described. Immunohistochemical studies demonstrated the gangliocytic portion of the tumor to be composed nearly entirely of ganglion cells enmeshed in their neuritic processes and disclosed focal presence of growth hormone and prolactin-secreting cells in the adenoma. Ultrastructurally, some of the larger ganglion cells contained (and were often filled with) zebra-like bodies, while the adenoma was shown to be sparsely granulated with numerous fibrous bodies. These findings support the term of mixed gangliocytoma-adenoma for these rare intrasellar tumors and provide additional support for their nature as independent neuroendocrine units.
本文描述了一例发生于垂体窝的混合性神经节细胞瘤-腺瘤，患者表现为肢端肥大症、溢乳和头痛。免疫组织化学研究表明，肿瘤的神经节细胞部分几乎完全由包埋在神经突起中的神经节细胞组成，并揭示腺瘤中存在局灶性生长激素和催乳素分泌细胞。超微结构上，一些较大的神经节细胞含有（且常充满）斑马样小体，而腺瘤显示为颗粒稀少，有许多纤维小体。这些发现支持将这些罕见的鞍内肿瘤称为混合性神经节细胞瘤-腺瘤，并为其作为独立神经内分泌单位的性质提供了更多支持。
