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一名极早产儿的短暂性新生儿糖尿病

Transient neonatal diabetes mellitus in an extremely preterm infant.

作者信息

Nishimaki S, Yukawa T, Makita Y, Honda H, Kikuchi N, Minamisawa S, Yokota S

机构信息

Department of Paediatrics, Yokohama City University, Yokohama, Japan.

出版信息

BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.11.2008.1185. Epub 2009 May 8.

Abstract

The present report concerns transient neonatal diabetes mellitus in an extremely preterm infant (gestational age 27 weeks, birth weight 718 g). The patient had intrauterine growth retardation and developed hyperglycaemia on the first day of life. Insulin administration was discontinued on the 89th day of life, which was 1 day before the original due date. This case suggests that (a) insufficient insulin secretion started at least from the second trimester of the pregnancy, and (b) the duration needed for recovery of insulin secretion was not dependent on the maturity.

摘要

本报告涉及一名极早产儿(胎龄27周,出生体重718克)的短暂性新生儿糖尿病。该患者存在宫内生长迟缓,出生第一天就出现了高血糖。在出生后第89天停止胰岛素给药,这比预产期提前了1天。该病例表明:(a)胰岛素分泌不足至少从妊娠中期就开始了;(b)胰岛素分泌恢复所需的时间并不取决于成熟度。

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本文引用的文献

1
Neonatal and very-early-onset diabetes mellitus.新生儿及极早发型糖尿病
Semin Neonatol. 2004 Feb;9(1):59-65. doi: 10.1016/S1084-2756(03)00064-2.
5
Aetiopathology and genetic basis of neonatal diabetes.新生儿糖尿病的病因病理学及遗传基础。
Arch Dis Child Fetal Neonatal Ed. 1997 Jan;76(1):F39-42. doi: 10.1136/fn.76.1.f39.
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An imprinted gene(s) for diabetes?
Nat Genet. 1995 Feb;9(2):110-2. doi: 10.1038/ng0295-110.
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Long-term course of neonatal diabetes.新生儿糖尿病的长期病程
N Engl J Med. 1995 Sep 14;333(11):704-8. doi: 10.1056/NEJM199509143331105.

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