[Disordered phosphorus metabolism and its correction in the acute period of severe craniocerebral trauma].

Marked hypophosphatemia was discovered in 78 patients in the acute period of severe craniocerebral injury. It led to a decrease of the level of 2,3-diphosphoglycerate (2,3 DPG) and ATP in the red cells. The reduced ATP level in the red cells was one of the causes of reduced Ca2+ ATPase activity in their membranes. Intravenous infusion of 6.8% potassium dihydrophosphate solution prevented the development of hypophosphatemia and reduction of the content of 2,3 DPG and ATP in the red cells and Ca2+ ATPase activity in their membranes, which facilitated improvement in the course of acute posttraumatic period in patients with severe craniocerebral injury and decrease of mortality.