Pas'ko S A, Volosheniuk T G
Zh Vopr Neirokhir Im N N Burdenko. 1990 May-Jun(3):14-6.
Marked hypophosphatemia was discovered in 78 patients in the acute period of severe craniocerebral injury. It led to a decrease of the level of 2,3-diphosphoglycerate (2,3 DPG) and ATP in the red cells. The reduced ATP level in the red cells was one of the causes of reduced Ca2+ ATPase activity in their membranes. Intravenous infusion of 6.8% potassium dihydrophosphate solution prevented the development of hypophosphatemia and reduction of the content of 2,3 DPG and ATP in the red cells and Ca2+ ATPase activity in their membranes, which facilitated improvement in the course of acute posttraumatic period in patients with severe craniocerebral injury and decrease of mortality.
在78例重型颅脑损伤急性期患者中发现明显的低磷血症。它导致红细胞内2,3 - 二磷酸甘油酸（2,3 - DPG）和三磷酸腺苷（ATP）水平降低。红细胞内ATP水平降低是其细胞膜上Ca2+ - ATP酶活性降低的原因之一。静脉输注6.8%磷酸二氢钾溶液可预防低磷血症的发生，防止红细胞内2,3 - DPG和ATP含量降低以及细胞膜上Ca2+ - ATP酶活性降低，这有助于重型颅脑损伤患者急性创伤后病程的改善并降低死亡率。
