Verma Sanjay, Garg Rakesh
Department of Anaesthesiology, All India Institute of Medical Sciences, New Delhi, India.
BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.10.2008.1029. Epub 2009 Mar 5.
The management of a patient with pre-existing deep venous thrombosis (DVT) who was subsequently found to have a malignancy planned for urgent laparotomy is reported.A 30-year-old woman presented to the emergency room and was diagnosed to have a DVT. During work-up, she was found to have a malignanacy and was scheduled for urgent laparotomy. The patient was put on enoxaprin (injection) and warfarin (tablets). The patient was started on heparin (injection) 1000 IU/h at 72 h prior to operation, stopped 6 h prior to surgery. Anaesthesia and surgery were uneventful.A number of issues related to pre-existing DVTs prior to gynaecological surgery require further clarification; the optimal duration of pharmacological treatment, and the optimal duration/modality of prophylaxis to prevent thromboembolism in high-risk patients with cancer.Patients presenting for DVT must be evaluated for its causative factor(s), and malignancy in particular, based on clinical findings and investigations. Before planning surgical procedures, adequate anticoagulation must be achieved to prevent further complications of DVT, thromboembolism and pulmonary embolism in particular.
本文报告了一名既往有深静脉血栓形成(DVT)的患者,该患者随后被发现患有恶性肿瘤并计划进行急诊剖腹手术。一名30岁女性因深静脉血栓形成到急诊室就诊,检查发现她患有恶性肿瘤并计划进行急诊剖腹手术。该患者接受了依诺肝素(注射剂)和华法林(片剂)治疗。患者在手术前72小时开始静脉滴注肝素(注射剂),剂量为1000IU/h,手术前6小时停用。麻醉和手术过程顺利。妇科手术前存在的深静脉血栓形成相关的一些问题需要进一步阐明;高危癌症患者预防血栓栓塞的药物治疗最佳持续时间,以及预防的最佳持续时间/方式。出现深静脉血栓形成的患者必须根据临床发现和检查评估其病因,尤其是恶性肿瘤。在计划手术前,必须进行充分的抗凝治疗,以预防深静脉血栓形成的进一步并发症,特别是血栓栓塞和肺栓塞。