Wei Christina Hsiao, Shoo Brenda A, Zedek Daniel C, Kashani-Sabet Mohammed, Sagebiel Richard W, Leong Stanley P L
UCSF Medical Center, Surgery Department, S-321, 513 Parnassus Avenue, San Francisco, California, 94143-0470, USA.
BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.09.2008.0981. Epub 2009 Feb 27.
A case of fatal metastatic melanoma arising from a very large congenital melanocytic naevus (VLCMN) is reported. Large congenital naevi (LCMN) are naevi >20 cm in diameter. VLCMN is used in this report to mean an extensive LCMN involving a large percentage of the body, including smaller so-called satellite naevi. A 19-year-old man with a large congenital melanocytic naevus (LCMN) presented with a new nodule on the left chest wall, which was diagnosed as a thick melanoma with synchronous axillary lymph-node metastasis. The patient developed widespread distant metastasis within weeks after surgical resection of the primary site and lymph-node basin, which was unresponsive to systemic chemotherapy and whole brain radiation therapy, and he died 7 months after diagnosis of the primary melanoma.
报告了一例源自非常大的先天性黑素细胞痣（VLCMN）的致命转移性黑色素瘤病例。大型先天性痣（LCMN）是指直径大于20 cm的痣。本报告中使用VLCMN表示广泛的LCMN，累及身体的很大一部分，包括较小的所谓卫星痣。一名患有大型先天性黑素细胞痣（LCMN）的19岁男性，左胸壁出现一个新结节，被诊断为伴有同步腋窝淋巴结转移的厚黑色素瘤。患者在原发部位和淋巴结区域手术切除后数周内发生广泛远处转移，对全身化疗和全脑放射治疗无反应，在原发性黑色素瘤诊断后7个月死亡。
