拉莫三嗪过量与全身性癫痫发作相关。
Lamotrigine overdose associated with generalised seizures.
作者信息
Waring William Stephen
机构信息
The Royal Infirmary of Edinburgh, Scottish Poisons Information Bureau, Edinburgh, EH16 4SA, UK.
出版信息
BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.07.2008.0489. Epub 2009 Feb 16.
Abstract
This report describes the occurrence of generalised seizures in a 42-year-old woman who presented to hospital after deliberate lamotrigine overdose. Seizure activity was promptly terminated after intravenous benzodiazepine administration, and the patient subsequently made a complete recovery. Serum lamotrigine concentration was 30 mg/l at 1.3 h post-ingestion, which is substantially higher than the therapeutic reference range; the estimated elimination half life was 18.3 h. This case reminds us that lamotrigine toxicity may provoke generalised seizures in susceptible individuals.
摘要
本报告描述了一名42岁女性在故意过量服用拉莫三嗪后出现全身性癫痫发作的情况。静脉注射苯二氮䓬后，癫痫活动迅速终止，患者随后完全康复。摄入后1.3小时血清拉莫三嗪浓度为30mg/L，远高于治疗参考范围；估计消除半衰期为18.3小时。该病例提醒我们，拉莫三嗪毒性可能在易感个体中引发全身性癫痫发作。
相似文献
1
Lamotrigine overdose associated with generalised seizures.拉莫三嗪过量与全身性癫痫发作相关。
BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.07.2008.0489. Epub 2009 Feb 16.
2
Seizures secondary to lamotrigine toxicity in a two-year-old.两岁儿童因拉莫三嗪毒性导致的癫痫发作。
Ann Pharmacother. 2010 Jun;44(6):1112-5. doi: 10.1345/aph.1M617. Epub 2010 Apr 20.
3
Acute lamotrigine overdose: a systematic review of published adult and pediatric cases.急性拉莫三嗪过量：已发表的成人和儿科病例系统评价。
Clin Toxicol (Phila). 2018 Feb;56(2):81-89. doi: 10.1080/15563650.2017.1370096. Epub 2017 Sep 1.
4
Report of Severe Menorrhagia Following the Maximum Amount of Lamotrigine Overdose.拉莫三嗪最大剂量过量服用后严重月经过多的报告。
Iran J Pharm Res. 2015 Fall;14(4):1289-93.
5
Lamotrigine overdose in an adult.一名成年人的拉莫三嗪过量服用情况。
J Toxicol Clin Toxicol. 2000;38(6):659-60. doi: 10.1081/clt-100102017.
6
Lamotrigine. An update of its pharmacology and therapeutic use in epilepsy.拉莫三嗪。其药理学及在癫痫治疗中应用的最新进展。
Drugs. 1995 Oct;50(4):691-713. doi: 10.2165/00003495-199550040-00008.
7
Lamotrigine-induced seizures in a child: case report and literature review.儿童拉莫三嗪诱发癫痫发作：病例报告及文献综述
Clin Toxicol (Phila). 2007;45(2):169-72. doi: 10.1080/15563650601006165.
8
Lamotrigine as a possible cause of QRS prolongation in a patient with known seizure disorder.拉莫三嗪可能是一名已知患有癫痫症患者QRS波延长的病因。
CJEM. 2006 Sep;8(5):361-4. doi: 10.1017/s1481803500014093.
9
Lamotrigine. A review of its pharmacological properties and clinical efficacy in epilepsy.拉莫三嗪。其药理学特性及在癫痫治疗中的临床疗效综述。
Drugs. 1993 Jul;46(1):152-76. doi: 10.2165/00003495-199346010-00009.
10
Safety profile of lamotrigine in overdose.拉莫三嗪过量使用时的安全性概况。
Ther Adv Psychopharmacol. 2016 Dec;6(6):369-381. doi: 10.1177/2045125316656707. Epub 2016 Aug 8.
引用本文的文献
1
Safety profile of lamotrigine in overdose.拉莫三嗪过量使用时的安全性概况。
Ther Adv Psychopharmacol. 2016 Dec;6(6):369-381. doi: 10.1177/2045125316656707. Epub 2016 Aug 8.
2
Rhabdomyolysis after lamotrigine overdose: a case report and review of the literature.拉莫三嗪过量后横纹肌溶解症：一例病例报告及文献综述
Ann Gen Psychiatry. 2016 Feb 24;15:6. doi: 10.1186/s12991-016-0093-3. eCollection 2016.
3
Case files of the University of California San Francisco Medical Toxicology Fellowship: lamotrigine toxicity.加利福尼亚大学旧金山分校医学毒理学奖学金病例档案：拉莫三嗪中毒
J Med Toxicol. 2012 Mar;8(1):52-8. doi: 10.1007/s13181-012-0210-x.
本文引用的文献
1
Seizures and altered mental status after lamotrigine overdose.拉莫三嗪过量服用后的癫痫发作和精神状态改变。
Ther Drug Monit. 2007 Dec;29(6):843-4. doi: 10.1097/FTD.0b013e31815bf239.
2
Lamotrigine intoxication provoking status epilepticus in an adult with localization-related epilepsy.拉莫三嗪中毒诱发一名患有局灶性相关性癫痫的成人癫痫持续状态。
Arch Neurol. 2007 Sep;64(9):1344-6. doi: 10.1001/archneur.64.9.1344.
3
Lamotrigine overdose in a child.一名儿童过量服用拉莫三嗪。
J Child Neurol. 2007 May;22(5):642-4. doi: 10.1177/0883073807302600.
4
Seizure aggravation in idiopathic generalized epilepsies.特发性全身性癫痫中的癫痫发作加重
Epilepsia. 2005;46 Suppl 9:133-9. doi: 10.1111/j.1528-1167.2005.00325.x.
5
Evaluation of lamotrigine toxicity reported to poison centers.向中毒控制中心报告的拉莫三嗪毒性评估。
Ann Pharmacother. 2004 Nov;38(11):1811-5. doi: 10.1345/aph.1E192. Epub 2004 Sep 7.
6
Stupor from lamotrigine toxicity.拉莫三嗪中毒所致木僵状态。
Epilepsia. 2001 Aug;42(8):1082-3. doi: 10.1046/j.1528-1157.2001.0420081082.x.
7
Lamotrigine overdose in an adult.一名成年人的拉莫三嗪过量服用情况。
J Toxicol Clin Toxicol. 2000;38(6):659-60. doi: 10.1081/clt-100102017.
8
Antiepileptic drugs as a cause of worsening seizures.抗癫痫药物作为癫痫发作恶化的一个原因。
Epilepsia. 1998 Jan;39(1):5-17. doi: 10.1111/j.1528-1157.1998.tb01268.x.
9
Lamotrigine. An update of its pharmacology and therapeutic use in epilepsy.拉莫三嗪。其药理学及在癫痫治疗中应用的最新进展。
Drugs. 1995 Oct;50(4):691-713. doi: 10.2165/00003495-199550040-00008.
10
Self-poisoning with lamotrigine.拉莫三嗪自服中毒。
Lancet. 1993;342(8886-8887):1552-3. doi: 10.1016/s0140-6736(05)80120-5.
Zotero 插件