Jazayeri Fiona, Malhotra Raman
St Thomas' Hospital, Ophthalmology, Westminster Bridge Road, London SE1 7EH, UK.
BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.01.2009.1473. Epub 2009 May 20.
A woman on erlotinib treatment for lung cancer presented with a corneal ulcer from aberrant eyelash touch. She developed coarse, hyperpigmented and irregular eyelash and eyebrow growth a few months following treatment. She was treated successfully with epilation, eyelash trimming, lid hygiene and intensive topical lubrication. This is the first case report in the UK of trichomegaly with associated corneal ulceration. Erlotinib is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that has recently been approved for use as a chemotherapeutic agent by the National Institute for Health and Clinical Excellence. Ophthalmologists and oncologists should be aware of the adnexal and ocular surface changes that can occur, and that simple interventions may be used to manage them.
一名接受厄洛替尼治疗肺癌的女性因异常睫毛接触出现角膜溃疡。治疗数月后,她出现睫毛和眉毛粗糙、色素沉着且不规则生长。通过拔毛、修剪睫毛、眼睑清洁和强化局部润滑,她得到了成功治疗。这是英国首例伴有角膜溃疡的睫毛粗长症病例报告。厄洛替尼是一种表皮生长因子受体(EGFR)酪氨酸激酶抑制剂,最近已被英国国家卫生与临床优化研究所批准用作化疗药物。眼科医生和肿瘤学家应意识到可能出现的附属器和眼表变化,以及可用于处理这些变化的简单干预措施。