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1
Severe iron intoxication treated with exchange transfusion.采用换血疗法治疗重度铁中毒。
BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.01.2009.1445. Epub 2009 May 8.
2
Severe iron intoxication treated with exchange transfusion.采用换血疗法治疗重度铁中毒。
Arch Dis Child. 2008 Apr;93(4):321-2. doi: 10.1136/adc.2007.123240.
3
Management of acute iron overdose.急性铁过量的管理。
Clin Pharm. 1989 Jun;8(6):428-40.
4
Survival after a severe iron poisoning treated with intermittent infusions of deferoxamine.用去铁胺间歇输注治疗严重铁中毒后的生存情况。
J Toxicol Clin Toxicol. 1995;33(1):61-6. doi: 10.3109/15563659509020217.
5
The use of haemofiltration for severe iron overdose.血液滤过在严重铁剂过量中的应用。
Arch Dis Child. 2010 Jun;95(6):482-3. doi: 10.1136/adc.2009.171454.
6
Severe iron poisoning treated with enteral and intravenous deferoxamine.
Ann Emerg Med. 1983 May;12(5):306-9. doi: 10.1016/s0196-0644(83)80515-0.
7
Successful treatment of severe iron intoxication with gastrointestinal decontamination, deferoxamine, and hemodialysis.经胃肠道去污、去铁胺和血液透析成功治疗严重铁中毒。
Ren Fail. 2013;35(5):729-31. doi: 10.3109/0886022X.2013.790299. Epub 2013 May 1.
8
Minimum ingested iron cut-off triggering serious iron toxicity in children.引发儿童严重铁中毒的最低摄入铁量临界值。
Pediatr Int. 2019 May;61(5):444-448. doi: 10.1111/ped.13834.
9
[Whole bowel irrigation in infants for acute iron poisoning].[婴儿急性铁中毒的全肠道灌洗]
Harefuah. 2000 May 15;138(10):837-41, 910.
10
Hepatotoxicity in acute iron poisoning.急性铁中毒中的肝毒性。
Hum Exp Toxicol. 2005 Nov;24(11):559-62. doi: 10.1191/0960327105ht564oa.

引用本文的文献

1
Near fatal iron intoxication managed conservatively.近致命性铁中毒采取保守治疗。
BMJ Case Rep. 2013 Jan 31;2013:bcr2012007670. doi: 10.1136/bcr-2012-007670.

本文引用的文献

1
Iron: not a benign therapeutic drug.铁：并非一种无害的治疗药物。
Curr Opin Pediatr. 2006 Apr;18(2):174-9. doi: 10.1097/01.mop.0000193275.62366.98.
2
FERROUS-SULPHATE POISONING TREATED BY EXCHANGE TRANSFUSION.
Lancet. 1964 Nov 7;2(7367):1015. doi: 10.1016/s0140-6736(64)90969-9.
3
Ferrous sulfate poisoning; report of a case successfully treated by exchange transfusion.硫酸亚铁中毒；一例通过换血成功治疗的病例报告。
J Pediatr. 1958 Oct;53(4):476-8. doi: 10.1016/s0022-3476(58)80241-3.
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Current applications of plasmapheresis in clinical toxicology.血浆置换在临床毒理学中的当前应用。
Nephrol Dial Transplant. 2003 Jul;18 Suppl 5:v56-8. doi: 10.1093/ndt/gfg1049.
5
Comparison of exchange transfusion and deferoxamine in the treatment of acute iron poisoning.
J Pediatr. 1969 Oct;75(4):604-8. doi: 10.1016/s0022-3476(69)80455-5.

采用换血疗法治疗重度铁中毒。

Severe iron intoxication treated with exchange transfusion.

作者信息

Carlsson M, Cortes D, Jepsen S, Kanstrup T

机构信息

Pediatric Intensive Care Unit, Odense University Hospital, Odense, Denmark.

出版信息

BMJ Case Rep. 2009;2009. doi: 10.1136/bcr.01.2009.1445. Epub 2009 May 8.

DOI:10.1136/bcr.01.2009.1445
PMID:21687019
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3029243/
Abstract

An 18-month-old previous healthy girl who had ingested 442 mg elemental iron/kg was admitted to a paediatric intensive care unit. The child was treated with gastric lavage, whole bowel irrigation and intravenous deferoxamine. After 2 h of standard therapy serum iron had risen threefold to 1362 µg/dl (244 µmol/l). The child was treated with exchange transfusion (ET; 52 ml/kg) and serum iron fell to 134 µg/dl (24 µmol/l). The patient made an uncomplicated recovery. ET should be considered in severe iron poisoning when standard therapy is inadequate.

摘要

一名18个月大、此前健康的女童摄入了442毫克元素铁/千克，被收治入儿科重症监护病房。该患儿接受了洗胃、全肠道灌洗及静脉注射去铁胺治疗。标准治疗2小时后，血清铁升高了两倍，达到1362微克/分升（244微摩尔/升）。该患儿接受了换血疗法（52毫升/千克），血清铁降至134微克/分升（24微摩尔/升）。患儿顺利康复。当标准治疗效果不佳时，严重铁中毒应考虑换血疗法。