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药物包封的聚对苯二甲酸乙二酯-聚乳酸纳米胶囊的抗癌研究

Anticancer studies of drug encapsulated polyethylene terephthalate-Co-polylactic acid nanocapsules.

作者信息

Kumar K Sathish, Kumar P Senthil, Vijayalakshmi S

机构信息

Department of Chemical Engineering, SSN College of Engineering, Kalavakkam-603 110, India.

出版信息

J Pharm Bioallied Sci. 2011 Apr;3(2):286-93. doi: 10.4103/0975-7406.80772.

DOI:10.4103/0975-7406.80772
PMID:21687360
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3103926/
Abstract

OBJECTIVES

The purpose of this study was to investigate the anticancer activity of anticancer drugs (5-fluorouracil and 6-thioguanine) in polymeric nanocapsules in the presence and in the absence of gold and iron oxide nanoparticles toward Hep2 cancer cells.

MATERIALS AND METHODS

MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay was used for quantitative measurements for the anticancer cell activity. Encapsulated drug in polyethylene terephthalate-polylactic acid copolymer (PET-co-PLA) nanocapsules in the presence and absence of gold and iron oxide nanoparticles were prepared via the W/O/W emulsification solvent-evaporation method. Morphology of the nanoparticles was characterized by transmission electron microscopy and scanning electron microscopy.

CONCLUSION

The average size of the polymeric nanocapsules, gold nanoparticles, and iron oxide nanoparticles were found to be in range of 230-260, 18 -20 nm, 5-10 nm, respectively. The findings in this study inferred that incorporated drug in polymeric nanocapsules with gold nanoparticles and iron oxide nanoparticles show better anticancer activity when compared with encapsulated drug in polymeric nanocapsules.

摘要

目的

本研究旨在探究在有和没有金纳米颗粒与氧化铁纳米颗粒存在的情况下，聚合物纳米胶囊中抗癌药物（5-氟尿嘧啶和6-硫鸟嘌呤）对Hep2癌细胞的抗癌活性。

材料与方法

采用MTT（3-[4,5-二甲基噻唑-2-基]-2,5-二苯基四氮唑溴盐）法对癌细胞活性进行定量测定。通过W/O/W乳化溶剂蒸发法制备了在有和没有金纳米颗粒与氧化铁纳米颗粒存在情况下，聚对苯二甲酸乙二酯-聚乳酸共聚物（PET-co-PLA）纳米胶囊中包封的药物。通过透射电子显微镜和扫描电子显微镜对纳米颗粒的形态进行表征。

结论

发现聚合物纳米胶囊、金纳米颗粒和氧化铁纳米颗粒的平均尺寸分别在230 - 260、18 - 20纳米、5 - 10纳米范围内。本研究结果表明，与聚合物纳米胶囊中包封的药物相比，聚合物纳米胶囊与金纳米颗粒和氧化铁纳米颗粒结合的药物显示出更好的抗癌活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37ff/3103926/21f3b74da4e0/JPBS-3-286-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37ff/3103926/a50e245c979d/JPBS-3-286-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37ff/3103926/03027235fbd0/JPBS-3-286-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37ff/3103926/1b3936c89f31/JPBS-3-286-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37ff/3103926/42fd05fd14db/JPBS-3-286-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37ff/3103926/6d668a3fa036/JPBS-3-286-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37ff/3103926/47b17ca6338f/JPBS-3-286-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37ff/3103926/21f3b74da4e0/JPBS-3-286-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37ff/3103926/a50e245c979d/JPBS-3-286-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37ff/3103926/03027235fbd0/JPBS-3-286-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37ff/3103926/1b3936c89f31/JPBS-3-286-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37ff/3103926/42fd05fd14db/JPBS-3-286-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37ff/3103926/6d668a3fa036/JPBS-3-286-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37ff/3103926/47b17ca6338f/JPBS-3-286-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37ff/3103926/21f3b74da4e0/JPBS-3-286-g009.jpg

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