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中风、高血压与肾素-血管紧张素-醛固酮系统——新进展

Stroke, high blood pressure and the Renin-Angiotensin-aldosterone system - new developments.

作者信息

Atkinson Jeffrey

机构信息

Pharmacology Laboratory, Pharmacy Faculty, Nancy University Villers, France.

出版信息

Front Pharmacol. 2011 Apr 27;2:22. doi: 10.3389/fphar.2011.00022. eCollection 2011.

DOI:10.3389/fphar.2011.00022
PMID:21687514
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3108479/
Abstract

This review considers whether a case can be made for a protective effect of inhibitors and blockers of the renin-angiotensin-aldosterone system (RAAS) on the cerebral circulation. It first looks at whether there exists a preferential effect on the cerebral circulation during a drug-induced lowering of high arterial blood pressure and cardiovascular morbi-mortality. It then goes on to consider background studies on the relationship between inhibition of the RAAS and stroke. This is followed by exploration of possible new directions in the inhibition of the RAAS and its effect on stroke.

摘要

本综述探讨了肾素-血管紧张素-醛固酮系统（RAAS）抑制剂和阻滞剂对脑循环是否具有保护作用。首先研究了在药物诱导的高动脉血压降低及心血管病病死率降低过程中，对脑循环是否存在优先效应。接着考虑了关于RAAS抑制与中风之间关系的背景研究。随后探索了RAAS抑制的可能新方向及其对中风的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9986/3108479/e54f9f32e217/fphar-02-00022-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9986/3108479/8dc5472b9363/fphar-02-00022-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9986/3108479/e614ef3c5bc7/fphar-02-00022-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9986/3108479/9538dbb86154/fphar-02-00022-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9986/3108479/e54f9f32e217/fphar-02-00022-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9986/3108479/8dc5472b9363/fphar-02-00022-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9986/3108479/e614ef3c5bc7/fphar-02-00022-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9986/3108479/9538dbb86154/fphar-02-00022-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9986/3108479/e54f9f32e217/fphar-02-00022-g004.jpg

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Aliskiren in the treatment of hypertension and organ damage.阿利吉仑治疗高血压及其器官损害。
Cardiovasc Ther. 2011 Feb;29(1):77-87. doi: 10.1111/j.1755-5922.2010.00230.x. Epub 2010 Nov 25.
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Renin-angiotensin system blockade and cognitive function in patients at high risk of cardiovascular disease: analysis of data from the ONTARGET and TRANSCEND studies.
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Lancet Neurol. 2011 Jan;10(1):43-53. doi: 10.1016/S1474-4422(10)70250-7. Epub 2010 Oct 25.
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Of fads, fashion, surrogate endpoints and dual RAS blockade.从时髦概念、时尚潮流、替代终点到双重 RAS 阻断。
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