Gigley Jason P, Bhadra Rajarshi, Khan Imtiaz A
Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington, DC 20037, USA.
J Parasitol Res. 2011;2011:243796. doi: 10.1155/2011/243796. Epub 2011 May 18.
CD8 T cells are essential for control of Toxoplasma gondii infection. Once activated they undergo differentiation into short-lived effector and memory precursor effector cells. As effector cells, CD8 T cells exert immune pressure on the parasite via production of inflammatory cytokines and through their cytolytic activity. Once immune control has been established, the parasite encysts and develops into chronic infection regulated by the memory CD8 T-cell population. Several signals are needed for this process to be initiated and for development of fully differentiated memory CD8 T cells. With newly developed tools including CD8 T-cell tetramers and TCR transgenic mice, dissecting the biology behind T. gondii-specific CD8 T-cell responses can now be more effectively addressed. In this paper, we discuss what is known about the signals required for effective T. gondii-specific CD8 T-cell development, their differentiation, and effector function.
CD8 T细胞对于控制弓形虫感染至关重要。一旦被激活，它们会分化为短命的效应细胞和记忆前体效应细胞。作为效应细胞，CD8 T细胞通过产生炎性细胞因子及其细胞溶解活性对寄生虫施加免疫压力。一旦建立了免疫控制，寄生虫就会形成包囊并发展为慢性感染，由记忆性CD8 T细胞群体进行调节。启动这一过程并使完全分化的记忆性CD8 T细胞发育需要多种信号。借助包括CD8 T细胞四聚体和TCR转基因小鼠在内的新开发工具，现在可以更有效地解析弓形虫特异性CD8 T细胞反应背后的生物学机制。在本文中，我们讨论了关于有效弓形虫特异性CD8 T细胞发育、分化及其效应功能所需信号的已知情况。
