Paley Chris, Taraskin Sergei, Elliott Stephen
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW UK.
J Chem Biol. 2010 Oct;3(4):189-94. doi: 10.1007/s12154-010-0042-6. Epub 2010 Jun 18.
In large asexual populations, clonal interference, whereby different beneficial mutations compete to fix in the population simultaneously, may be the norm. Results extrapolated from the spread of individual mutations in homogeneous backgrounds are found to be misleading in such situations: clonal interference severely inhibits the spread of beneficial mutations. In contrast with results gained in systems with just one mutation striving for fixation at any one time, the spatial structure of the population is found to be an important factor in determining the fixation probability when there are two beneficial mutations.
在大型无性繁殖群体中，克隆干扰可能是常态，即不同的有益突变会同时竞争在群体中固定下来。在这种情况下，从单个突变在同质背景中的传播推断出的结果会产生误导：克隆干扰会严重抑制有益突变的传播。与在任何时刻只有一个突变力争固定的系统中获得的结果相反，当存在两个有益突变时，群体的空间结构被发现是决定固定概率的一个重要因素。
