Department of Reproductive Medicine, First Affiliated Hospital of the Medical School of Xi'an Jiaotong University, Xi'an, Shaanxi, PR China.
Oncol Rep. 2011 Sep;26(3):717-24. doi: 10.3892/or.2011.1345. Epub 2011 Jun 15.
CD147, a multifunction glycoprotein of the immuno-globulin family, is associated with many types of tumors, and the overexpression of CD147 can enhance malignancy. However, the role of CD147 in cervical cancer remains unclear. In the present study, cervical cancer cells were found to express much more CD147 protein and isoform‑4 than normal cervical cells (P<0.05), suggesting that CD147 and isoform‑4 are involved in cervical cancers. Furthermore, we overexpressed the CD147 isoform‑4 (CD147‑4) in the cervical cancer cell line SiHa by transfection and found that CD147-4 promoted the proliferation of SiHa cells with a considerable proportion of cells in the S phase in which the expression of CIP2A, Plk and cyclin D1 was up-regulated while the expression of P27 was down-regulated. This may be one of the molecular mechanisms involved in cervical cancer progression by CD147.
CD147 是免疫球蛋白家族的一种多功能糖蛋白，与多种类型的肿瘤相关，其过表达可增强肿瘤的恶性程度。然而，CD147 在宫颈癌中的作用尚不清楚。本研究发现，宫颈癌细胞中 CD147 蛋白及其异构体 4 的表达明显高于正常宫颈细胞（P<0.05），提示 CD147 和异构体 4 参与宫颈癌的发生。进一步通过转染在宫颈癌 SiHa 细胞中过表达 CD147 异构体 4（CD147-4），发现 CD147-4 可促进 SiHa 细胞的增殖，S 期细胞比例显著增加，同时 CIP2A、Plk 和 cyclin D1 的表达上调，而 P27 的表达下调。这可能是 CD147 促进宫颈癌进展的分子机制之一。
