Aringer M, Hiepe F
Medizinische Klinik und Poliklinik III, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland.
Z Rheumatol. 2011 Jun;70(4):313-23. doi: 10.1007/s00393-011-0794-6.
Systemic lupus erythematosus (SLE) is the classical systemic autoimmune disease. Its prevalence is slightly below 1:1,000 in women and 10-fold lower in men. Typically, the disease manifests in women of childbearing age. While severe untreated SLE used to be a fatal disease, prognosis has improved stepwise with corticosteroids, cyclophosphamide and novel therapies. Deaths directly related to SLE are uncommon nowadays but infections, thromboses and accelerated atherosclerosis cause significant problems. The current review presents the state of the art in managing SLE patients.
系统性红斑狼疮（SLE）是典型的全身性自身免疫性疾病。其在女性中的患病率略低于千分之一，在男性中则低10倍。通常，该疾病在育龄女性中表现出来。虽然严重的未经治疗的SLE曾经是一种致命疾病，但随着皮质类固醇、环磷酰胺和新型疗法的出现，预后已逐步改善。如今，与SLE直接相关的死亡并不常见，但感染、血栓形成和加速的动脉粥样硬化会引发重大问题。本综述介绍了SLE患者管理的最新进展。
