在一个稳定表达系统中，皮质类固醇可刺激乙肝病毒DNA、信使核糖核酸及蛋白质的生成。
Corticosteroids stimulate hepatitis B virus DNA, mRNA and protein production in a stable expression system.
作者信息
Tur-Kaspa R, Laub O
机构信息
Department of Medicine A, Hadassah University Hospital, Jerusalem, Israel.
出版信息
J Hepatol. 1990 Jul;11(1):34-6. doi: 10.1016/0168-8278(90)90268-v.
The effect of corticosteroids (Dexamethasone) on hepatitis B virus was investigated in human hepatoblastoma cells stable transfected with recombinant HBV DNA. Dexamethasone was found to cause elevation of HBsAg, HBeAg and viral DNA production. HBV poly(A)+ RNA was significantly increased in cells treated with Dexamethasone. Furthermore, pulse labelled nuclear HBV RNA was also stimulated by Dexamethasone. These findings, suggest that corticosteroids enhance expression of viral gene products by stimulating HBV transcription.
在稳定转染重组乙肝病毒（HBV）DNA的人肝癌细胞中研究了皮质类固醇（地塞米松）对乙肝病毒的作用。发现地塞米松可导致乙肝表面抗原（HBsAg）、乙肝e抗原（HBeAg）及病毒DNA产生量升高。在用其处理的细胞中，HBV多聚腺苷酸化（poly(A)+）RNA显著增加。此外，脉冲标记的细胞核HBV RNA也受到地塞米松的刺激。这些发现表明，皮质类固醇通过刺激HBV转录增强病毒基因产物的表达。
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