Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, Denmark.
BMC Ophthalmol. 2011 Jun 20;11:17. doi: 10.1186/1471-2415-11-17.
To report a case of keratitis and a case of conjunctivitis caused by synthetic fibers from toy teddy bears.
Case stories with histopathological analysis. 1) A two-year-old girl developed a severe case of keratitis and corneal ulceration. The initial treatment with various antibiotics gave no improvement and eventually the patient developed spontaneous perforation of the cornea. The corneal swabs contained no bacteria or fungi. Corneal grafting was performed and the corneal button was sent for histopathological examination. 2) A five-year-old girl presented with ocular irritation in her left eye. Examination revealed a conjunctival granuloma in the inferior fornix. The lesion was excised and histopathologically examined.
Microscopy revealed synthetic fibers embedded in the cornea and in the conjunctival granuloma. The diagnosis was confirmed by demonstration of marked birefringence of the synthetic fibers. Microscopical examination of synthetic fibers from two different types of fur (whiskers and face hairs) from the two-year-old girl's teddy bear was performed. Hairs from the face of the teddy bear were morphologically and microscopically identical with the fibers causing the severe corneal ulceration in the two-year-old girl.
Doctors should especially in small children be aware of the risk of ocular consequences of close exposure of synthetic fibers from stuffed toy animals. Corneal ulceration, clinically presenting as corneal infection with negative culturing and staining, should lead to a different clinical strategy and treatment. The treatment of conjunctival synthetic fiber granuloma is excision and antibiotic eye drops.
报告一起由玩具泰迪熊的合成纤维引起的角膜炎和结膜炎病例。
附有组织病理学分析的病例故事。1)一名两岁女孩患严重角膜炎和角膜溃疡。最初用各种抗生素治疗没有改善,最终患者发生了角膜自发性穿孔。角膜拭子未检出细菌或真菌。进行了角膜移植,将角膜瓣送去做组织病理学检查。2)一名五岁女孩左眼出现眼部刺激症状。检查发现下穹窿有结膜肉芽肿。切除病变并进行组织病理学检查。
显微镜下发现合成纤维嵌入角膜和结膜肉芽肿中。通过显示合成纤维的明显双折射证实了诊断。对来自两岁女孩的泰迪熊的两种不同类型的毛(胡须和面部毛发)的合成纤维进行了显微镜检查。泰迪熊面部的毛发在形态和微观上与导致两岁女孩严重角膜溃疡的纤维相同。
医生应特别注意儿童近距离接触填充玩具动物的合成纤维对眼部的潜在危害。临床表现为培养和染色均为阴性的角膜感染的角膜溃疡,应采取不同的临床策略和治疗方法。结膜合成纤维肉芽肿的治疗方法是切除和抗生素眼药水滴眼。