Laboratory of Stress Research, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia.
FEBS Lett. 2011 Jul 21;585(14):2279-84. doi: 10.1016/j.febslet.2011.06.001. Epub 2011 Jun 16.
Catecholamines are an important regulator of lipolysis in adipose tissue. Here we show that rat adipocytes, isolated from mesenteric adipose tissue, express genes of catecholamine biosynthetic enzymes and produce catecholamines de novo. Administration of tyrosine hydroxylase inhibitor, alpha-methyl-p-tyrosine, in vitro significantly reduced concentration of catecholamines in isolated adipocytes. We hypothesize that the sympathetic innervation of adipose tissues is not the only source of catecholamines, since adipocytes also have the capacity to produce both norepinephrine and epinephrine.
儿茶酚胺是脂肪组织脂解作用的重要调节剂。在这里，我们表明，从小肠脂肪组织分离的大鼠脂肪细胞表达儿茶酚胺生物合成酶的基因，并从头合成儿茶酚胺。在体外给予酪氨酸羟化酶抑制剂α-甲基-对酪氨酸，可显著降低分离的脂肪细胞中儿茶酚胺的浓度。我们假设脂肪组织的交感神经支配不是儿茶酚胺的唯一来源，因为脂肪细胞也有产生去甲肾上腺素和肾上腺素的能力。
