Istituto di Biostrutture e Bioimmagini - CNR, Via Mezzocannone 16, 80134 Napoli, Italy.
Int J Pharm. 2011 Aug 30;415(1-2):206-10. doi: 10.1016/j.ijpharm.2011.06.007. Epub 2011 Jun 13.
In this work, we report a technological approach to a novel Fmoc-protected nucleoamino acid, based on l-tyrosine, carrying the DNA nucleobase on the hydroxyl group by means of an ester bond, suitable for the solid-phase synthesis of novel aromatic nucleopeptides of potential interest in biomedicine. After ESI-MS and NMR characterization this building block was used for the assembly of a thymine-functionalized tetrapeptide, composed of nucleobase-containing and underivatized l-tyrosine moieties alternated in the backbone.
在这项工作中，我们报告了一种基于 l-酪氨酸的新型 Fmoc 保护核氨基酸的技术方法，该方法通过酯键将 DNA 碱基连接到羟基上，适用于新型芳香族核肽的固相合成，这些核肽在生物医药领域具有潜在的应用价值。通过 ESI-MS 和 NMR 表征，该砌块被用于组装胸腺嘧啶功能化的四肽，该四肽由碱基含有和未衍生的 l-酪氨酸部分交替组成的主链。
