Gierasch Tiffany Malinky, Shi Zhangjie, Verdine Gregory L
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
Org Lett. 2003 Mar 6;5(5):621-4. doi: 10.1021/ol027116f.
The syntheses of stereodiverse libraries of 12 and 19 are reported, where each asterisk represents an independently varied stereocenter. These scaffolds provide additional templates for investigations of geometric diversity in library syntheses. Libraries of these N-Fmoc-amino acids were further functionalized by incorporation into a peptide sequence, demonstrating the utility of 12 and 19 as building blocks for diversity oriented synthesis.
报道了12和19的立体多样文库的合成，其中每个星号代表一个独立变化的立体中心。这些支架为文库合成中几何多样性的研究提供了额外的模板。这些N-芴甲氧羰基氨基酸文库通过并入肽序列进一步功能化，证明了12和19作为多样性导向合成的构建块的实用性。
