Clinical Neuroanatomy, Center for Clinical Research, Department of Neurology, University of Ulm, Helmholtzstrasse 8/1, 89081 Ulm, Germany.
Acta Neuropathol. 2010 Jun;119(6):703-13. doi: 10.1007/s00401-010-0665-2. Epub 2010 Mar 14.
A retrospective autopsy-based study of the human submandibular gland, one of the three major salivary glands, together with anatomically related peripheral structures (cervical superior ganglion, cervical sympathetic trunk, vagal nerve at the level of the carotid bifurcation), was conducted on a cohort consisting of 33 individuals, including 9 patients with neuropathologically confirmed Parkinson's disease (PD), three individuals with incidental Lewy body disease (iLBD), 2 individuals with neuropathologically confirmed multiple system atrophy (MSA), and 19 controls, using alpha-synuclein immunohistochemistry in 100 mum polyethylene glycol-embedded tissue sections. Lewy pathology (LP) was present in the submandibular glands and cervical superior ganglia in PD (9/9 cases) and iLBD (2/3 cases) but not in MSA or controls. The cervical sympathetic trunk (7/9 PD cases, 2/3 iLBD cases) and peripheral vagal nerves (9/9 PD cases, 2/3 iLBD cases) also displayed LP. The results are discussed within the context of hyposmia as well as autonomic dysfunction in PD (sialorrhea, sialopenia, dysphagia). Potential disease-related changes in salivary volume, contents, and viscosity might make it possible, in combination with other tests, to employ human saliva as a biomarker.
对人体下颌下腺（三大唾液腺之一），以及解剖相关的周围结构（颈上神经节、颈交感干、颈动脉分叉处的迷走神经）进行了回顾性尸检研究。该研究队列包括 33 个人，其中 9 人患有神经病理学确诊的帕金森病（PD），3 人患有偶发路易体病（iLBD），2 人患有神经病理学确诊的多系统萎缩（MSA），19 人作为对照。使用 alpha-synuclein 免疫组织化学方法，对 100 微米聚乙二醇包埋的组织切片进行分析。下颌下腺和颈上神经节中存在路易体病理（LP），这在 PD（9/9 例）和 iLBD（2/3 例）中均可见，但在 MSA 或对照组中未发现。颈交感干（7/9 PD 病例，2/3 iLBD 病例）和周围迷走神经（9/9 PD 病例，2/3 iLBD 病例）也显示出 LP。结果在 PD 的嗅觉减退以及自主神经功能障碍的背景下进行了讨论（流涎、唾液减少、吞咽困难）。唾液量、成分和黏度的潜在疾病相关变化可能使其有可能与其他测试相结合，将人唾液用作生物标志物。
